{"id":"W3118375212","doi":"10.1016/j.plefa.2020.102235","title":"Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure","year":2021,"lang":"en","type":"article","venue":"Prostaglandins Leukotrienes and Essential Fatty Acids","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"National Eye Institute; Allergan","keywords":"Prostaglandin; Intraocular pressure; Internal medicine; Thromboxane-A synthase; Endocrinology; Prostaglandin D2; Chemistry; Enzyme; Thromboxane A2; Molecular biology; Biology; Biochemistry; Medicine; Surgery; Arachidonic acid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131514,0.0006019969,0.0003486021,0.0004212254,0.0002287768,0.0003478326,0.0004942646,0.000503409,0.00187694],"category_scores_gemma":[0.0002207553,0.0003800787,0.0003439552,0.0002087306,0.0006343191,0.0002041023,0.000270889,0.001090623,0.0006018901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599241,"about_ca_system_score_gemma":0.0004018624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072472,"about_ca_topic_score_gemma":0.001070285,"domain_scores_codex":[0.9998682,0.0000177458,0.0000168609,0.00002711827,0.00003889183,0.0000313253],"domain_scores_gemma":[0.9996544,0.0001414069,0.00008888583,0.00003198035,0.0000142266,0.0000691217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001667872,0.00002728554,0.0001284816,0.000009932659,0.000003255786,0.0001886919,0.000008271612,0.0000991698,0.9985301,0.0001435483,0.00001696539,0.0006775914],"study_design_scores_gemma":[0.0000782216,0.0001967301,0.006439395,0.000009643086,0.00003956626,0.001264615,0.0000468093,0.002147544,0.9878497,0.0001661946,0.001745062,0.00001659648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891995,0.0003844045,0.008213168,0.0001814716,0.0000517278,0.00003114341,0.0007722808,0.0001232703,0.001043076],"genre_scores_gemma":[0.9883327,0.0005344924,0.005161704,0.00007794441,0.00002786686,0.00004071758,0.001598946,0.0001406409,0.004085045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187694,"threshold_uncertainty_score":0.006279051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00861493167100385,"score_gpt":0.2499152200807923,"score_spread":0.2413002884097885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}