{"id":"W3118419952","doi":"10.1093/ofid/ofaa439.053","title":"8. Higher hepatitis B antibody titres induced in all adults vaccinated with a tri-antigenic hepatitis B (HBV) vaccine, compared to a mono-antigenic HBV vaccine: results from two pivotal phase 3 double-blind, randomized studies (PROTECT and CONSTANT)","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Variation Biotechnologies (Canada); Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Medicine; Vaccination; Hepatitis B virus; Immunogenicity; Antigen; Hepatitis B; Hepatitis B vaccine; Immunology; Antibody; Titer; Virology; HBsAg; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005039823,0.0009668985,0.00196261,0.0003178104,0.0002232782,0.0006873518,0.0004018312,0.00188541,0.004047758],"category_scores_gemma":[0.003380289,0.0004716397,0.003212014,0.0002175183,0.000689956,0.0009855293,0.0003143693,0.001923711,0.0005258025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220487,"about_ca_system_score_gemma":0.0006192984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000268764,"about_ca_topic_score_gemma":0.0004356881,"domain_scores_codex":[0.9977763,0.001276484,0.0002639026,0.0003020624,0.0001627802,0.0002183833],"domain_scores_gemma":[0.9960371,0.001750254,0.0009058832,0.0003554323,0.0003545344,0.000596942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9503606,0.01004903,0.002811833,0.0007887278,0.001600313,0.00003037647,0.00006142012,0.0001957662,0.01205234,0.00007589481,0.0006159478,0.02135777],"study_design_scores_gemma":[0.4002498,0.5655977,0.02284546,0.0001157233,0.002636151,0.00009320975,0.00004166833,0.0004394548,0.006932276,0.0001361519,0.0008860134,0.00002641009],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925236,0.003167335,0.0007592982,0.0003768881,0.0004773422,0.001126506,0.0004756227,0.00008567754,0.00100781],"genre_scores_gemma":[0.9957477,0.0008247298,0.00084584,0.0003687586,0.0002440968,0.0004741005,0.0004539022,0.00001347621,0.00102741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005039823,"threshold_uncertainty_score":0.02665347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05210491772358723,"score_gpt":0.3663324735772323,"score_spread":0.314227555853645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}