{"id":"W3118458521","doi":"10.1097/01.cot.0000732992.19180.64","title":"Germline Testing for Lynch Syndrome in Endometrial &amp; Ovarian Cancers","year":2021,"lang":"en","type":"article","venue":"Oncology Times","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lynch syndrome; Endometrial cancer; MSH6; MLH1; Ovarian cancer; Germline mutation; PMS2; Medicine; Population; Oncology; MSH2; Epithelial cell adhesion molecule; Cancer; Colorectal cancer; Cancer research; Cancer syndrome; Microsatellite instability; Internal medicine; Gynecology; DNA mismatch repair; Biology; Mutation; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003785176,0.0001504657,0.0005336173,0.0001968294,0.00005010368,0.000009456215,0.00008922119,0.0002381856,0.001451512],"category_scores_gemma":[0.003726624,0.0001481983,0.00009077529,0.0006841674,0.00009038726,0.00002664461,0.00006356677,0.0002459784,0.00004524194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009323984,"about_ca_system_score_gemma":0.002003175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000186435,"about_ca_topic_score_gemma":0.000780938,"domain_scores_codex":[0.9986354,0.00007808843,0.0003555477,0.0003826921,0.0001586845,0.0003895567],"domain_scores_gemma":[0.9979771,0.00135993,0.00009640782,0.0002499146,0.0002005821,0.0001160767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006078911,0.001774442,0.4259095,0.0008739502,0.001071035,0.004697317,0.001750761,0.001442251,0.236174,0.0009313726,0.08387259,0.2354239],"study_design_scores_gemma":[0.0390109,0.008969137,0.2501774,0.0005103316,0.0006440032,0.005684288,0.0003547218,0.001514189,0.01967836,0.002619356,0.6698242,0.001013206],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565871,0.001184682,0.0002790895,0.003063528,0.001849184,0.0008189589,0.00003481055,0.0000713798,0.03611127],"genre_scores_gemma":[0.9229116,0.0000250983,0.06485088,0.0007661192,0.0004270177,0.00023447,0.00006277527,0.00003557176,0.01068642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5859516,"threshold_uncertainty_score":0.9994613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05817849070532381,"score_gpt":0.3519003296958853,"score_spread":0.2937218389905614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}