{"id":"W3118496727","doi":"10.1212/wnl.0000000000011524","title":"Temporal Dynamics of β-Amyloid Accumulation in Aging and Alzheimer Disease","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Bristol-Myers Squibb; Eli Lilly and Company; Medpace; Biogen; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Alzheimer's disease; Amyloid (mycology); Neuroscience; Disease; Dynamics (music); Amyloid β; Medicine; Biology; Pathology; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009849215,0.0001292969,0.0001691536,0.0009966998,0.0002755217,0.0005607666,0.0001864239,0.0003472316,0.0009639651],"category_scores_gemma":[0.00298975,0.000179666,0.0002014666,0.0008561335,0.000226877,0.0005928388,0.0004151151,0.0003011964,0.0002214373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000299937,"about_ca_system_score_gemma":0.0002830491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009068543,"about_ca_topic_score_gemma":0.008961881,"domain_scores_codex":[0.9997683,0.00006662464,0.00002677875,0.00006032016,0.00004349126,0.00003441492],"domain_scores_gemma":[0.9985293,0.0003435332,0.0006610018,0.000110859,0.0002122293,0.0001430222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000454989,0.00002907667,0.9896591,0.00002454076,0.00004710427,0.0001243487,0.0002494707,0.00029979,0.001544844,0.0001570523,0.0002121283,0.007197526],"study_design_scores_gemma":[0.000002338675,0.0000569521,0.9983052,0.000005555485,0.00001088908,0.0002474073,0.0001300348,0.0005584856,0.0002070492,0.0001791004,0.0002919511,0.000005011792],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967003,0.001100601,0.0004838009,0.0001110512,0.000005337131,0.000009312616,0.0007361394,0.00001586131,0.0008375598],"genre_scores_gemma":[0.9984725,0.0003434071,0.0003760477,0.00002342314,0.00001005888,0.000007270156,0.0005725922,0.000003241353,0.0001913422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009068543,"threshold_uncertainty_score":0.01803154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458034157105095,"score_gpt":0.3469656722704824,"score_spread":0.3023853306994314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}