{"id":"W3118512908","doi":"10.3390/toxins13010055","title":"Mapping the DNA-Binding Motif of Scabin Toxin, a Guanine Modifying Enzyme from Streptomyces scabies","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Brock University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Guanine; Streptomyces coelicolor; Biology; DNA; Biochemistry; Binding site; NAD+ kinase; Base pair; Streptomyces; Enzyme; Nucleotide; Mutant; Genetics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000353652,0.0003172611,0.0005350884,0.0001361743,0.0004649815,0.0000601753,0.0005509731,0.0002957809,0.003577197],"category_scores_gemma":[0.0002280523,0.0002478415,0.0002502745,0.0004117523,0.0002548006,0.0001891203,0.000394612,0.0004560733,0.0003823801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006027299,"about_ca_system_score_gemma":0.0001220093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003158021,"about_ca_topic_score_gemma":0.00013033,"domain_scores_codex":[0.997916,0.0002898842,0.0006140574,0.0005081252,0.0001072205,0.0005647009],"domain_scores_gemma":[0.9984191,0.0003359182,0.0002879511,0.0007980841,0.0001266238,0.00003231662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003134425,0.0001368514,0.0006483226,0.00002275991,0.0003183998,0.00001438877,0.002717396,0.00002047971,0.9879516,0.002118237,0.0008917302,0.005128428],"study_design_scores_gemma":[0.00107913,0.00007865296,0.004874907,0.0001822904,0.0000583312,0.00004320972,0.007150556,0.00004744052,0.9693365,0.0007552121,0.01609796,0.0002957706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988543,0.006317548,0.0008612801,0.0005955918,0.001130846,0.0002364994,0.0002469459,0.0001215168,0.001946709],"genre_scores_gemma":[0.9927627,0.0002164854,0.001001875,0.0002158917,0.0000947468,0.00002785921,0.0002218848,0.0000398507,0.00541866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01861512,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708666657294679,"score_gpt":0.2322308416870107,"score_spread":0.2051441751140639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}