{"id":"W3118514290","doi":"10.1158/1078-0432.ccr-20-2378","title":"Double-hit Signature with <i>TP53</i> Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College; CancerCare Manitoba","funders":"National Cancer Institute; National Institutes of Health; City of Hope","keywords":"Diffuse large B-cell lymphoma; Rituximab; Vincristine; Lymphoma; Germinal center; Cell of origin; Oncology; Medicine; Internal medicine; PTEN; Cancer research; Cyclophosphamide; Biology; B cell; Cancer; Immunology; Chemotherapy; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002207418,0.0002206247,0.0002577043,0.0005102365,0.0001968912,0.000339275,0.0001797057,0.0002392211,0.0004806297],"category_scores_gemma":[0.0006095881,0.0001279888,0.0001514192,0.0003718862,0.0002555151,0.0001797016,0.0002762319,0.0002157305,0.0001097877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001704789,"about_ca_system_score_gemma":0.0001395868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044073,"about_ca_topic_score_gemma":0.0008956596,"domain_scores_codex":[0.9998683,0.00002790635,0.00001357328,0.00003925096,0.00002381277,0.00002710221],"domain_scores_gemma":[0.9996922,0.00006308586,0.0001178436,0.00002581662,0.00002685226,0.00007428641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001874558,0.00001292086,0.9953863,0.000004573604,0.0000177856,0.000267028,0.00002687918,0.00006802005,0.002547811,0.000005399208,0.00002935584,0.001446526],"study_design_scores_gemma":[0.00001164511,0.0001253825,0.996639,0.00000218172,0.00002923288,0.002112904,0.00007669267,0.0003679867,0.0005052693,0.00002270255,0.0001047122,0.000002240338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997622,0.00007268583,0.00004624914,0.000007054638,7.262084e-7,0.000001852222,0.00002900702,0.000002026771,0.0000781282],"genre_scores_gemma":[0.9998397,0.00001748926,0.00004293453,0.000006143719,0.000002097052,0.000001171804,0.00007630826,6.654728e-7,0.00001351741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007044073,"threshold_uncertainty_score":0.001607835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06245815259684164,"score_gpt":0.3858503799449771,"score_spread":0.3233922273481355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}