{"id":"W3118514290","doi":"10.1158/1078-0432.ccr-20-2378","title":"Double-hit Signature with <i>TP53</i> Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College; CancerCare Manitoba","funders":"National Cancer Institute; National Institutes of Health; City of Hope","keywords":"Diffuse large B-cell lymphoma; Rituximab; Vincristine; Lymphoma; Germinal center; Cell of origin; Oncology; Medicine; Internal medicine; PTEN; Cancer research; Cyclophosphamide; Biology; B cell; Cancer; Immunology; Chemotherapy; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006666809,0.0003512618,0.0007788104,0.0001572052,0.0001560126,0.00009116506,0.000193206,0.0002699482,0.0003349164],"category_scores_gemma":[0.00008002273,0.000204855,0.0001003653,0.001005224,0.0003715953,0.0001567586,0.0001515624,0.0006459226,0.00003958006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236683,"about_ca_system_score_gemma":0.001760773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008565316,"about_ca_topic_score_gemma":0.002704923,"domain_scores_codex":[0.9955703,0.0004105666,0.0005394672,0.0008771124,0.001586621,0.001015924],"domain_scores_gemma":[0.9968449,0.0005286192,0.0001150508,0.0006357012,0.0013317,0.0005440377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03516868,0.02075854,0.9368461,0.0001803159,0.0003076976,0.002829199,0.0001661294,0.000002512121,0.000004188286,0.00003346587,0.001785338,0.001917847],"study_design_scores_gemma":[0.1485175,0.005993438,0.835402,0.0008166941,0.0001676907,0.00002603982,0.0002508681,0.0000159614,0.0007783251,0.000002810795,0.007764549,0.0002641222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931623,0.0008517512,0.000001167691,0.0008623156,0.0001205795,0.001022622,0.0002072037,0.00004748691,0.003724608],"genre_scores_gemma":[0.9941036,0.0005229855,0.00006950302,0.0005565242,0.0002376086,0.0002561668,0.0003655127,0.00007529969,0.003812825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133488,"threshold_uncertainty_score":0.8353746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06245815259684164,"score_gpt":0.3858503799449771,"score_spread":0.3233922273481355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}