{"id":"W3118523456","doi":"10.3390/biom11010106","title":"From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Organoid; Disease; Biology; Strain (injury); Pathogenesis; Neuroscience; Prion protein; Computational biology; Immunology; Medicine; Pathology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006203082,0.001066505,0.001544286,0.002624672,0.0002334243,0.001194371,0.0008694354,0.001103899,0.002351959],"category_scores_gemma":[0.0005912371,0.0003293171,0.0005411372,0.002148305,0.0005623783,0.001488977,0.0007844816,0.001814093,0.003057349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006311851,"about_ca_system_score_gemma":0.0006161733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000741561,"about_ca_topic_score_gemma":0.001101407,"domain_scores_codex":[0.9997707,0.00004158929,0.00003169185,0.00004736519,0.00009220714,0.00001645308],"domain_scores_gemma":[0.9996539,0.000194035,0.00003403065,0.00001827675,0.00007636892,0.00002327164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001027113,0.0001063456,0.000298721,0.03174139,0.0001045668,0.0004792796,0.0001597113,0.0006594657,0.02551083,0.01243845,0.02249263,0.9059059],"study_design_scores_gemma":[0.00001027525,0.0001172325,0.0005339323,0.002396918,0.00009669409,0.001389889,0.00006172354,0.00007925829,0.005367172,0.002493151,0.9874275,0.00002638739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002556602,0.9967062,0.0006253379,0.0001479964,0.0001986897,0.00001153644,0.0000564143,0.00001935094,0.001978862],"genre_scores_gemma":[0.0009928179,0.9970795,0.000662551,0.0001398407,0.00008353488,0.00001937524,0.00009233655,0.000005216679,0.0009248642],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002624672,"threshold_uncertainty_score":0.007868111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03947012786338254,"score_gpt":0.3295125068666494,"score_spread":0.2900423790032668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}