{"id":"W3118535436","doi":"10.3390/ijms22020689","title":"Paternal Methyl Donor Supplementation in Rats Improves Fertility, Physiological Outcomes, Gut Microbial Signatures and Epigenetic Markers Altered by High Fat/High Sucrose Diet","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Offspring; Endocrinology; Internal medicine; Biology; Epigenetics; Adipose tissue; Obesity; Fertility; Medicine; Pregnancy; Genetics; Gene; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002585011,0.0006218368,0.0006398607,0.0004967518,0.0002691857,0.0002925182,0.0003863694,0.000470752,0.002421631],"category_scores_gemma":[0.0002447585,0.000395977,0.0004133683,0.0001361583,0.0004401174,0.0003418982,0.0003634166,0.001322551,0.0003831658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489437,"about_ca_system_score_gemma":0.0004474967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680215,"about_ca_topic_score_gemma":0.003573853,"domain_scores_codex":[0.9997604,0.00003176218,0.0000194728,0.00007198531,0.00004920793,0.00006718496],"domain_scores_gemma":[0.9995866,0.00002011351,0.0001231519,0.00004911733,0.00004269073,0.0001783234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004812711,0.0006690017,0.001732368,0.000077116,0.00003946288,0.0001100956,0.0000665379,0.00007249907,0.9858963,0.00009370453,0.0001293425,0.006300881],"study_design_scores_gemma":[0.0003528246,0.02023069,0.03755606,0.00006071332,0.0002466849,0.0004851763,0.0004242141,0.001322083,0.9349045,0.0002893514,0.004073799,0.00005395352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971312,0.0004987111,0.001228967,0.000134692,0.00006279178,0.00001862075,0.0003937146,0.0001056087,0.0004256424],"genre_scores_gemma":[0.9892184,0.0007878323,0.002607606,0.0002231562,0.00002445553,0.00009185884,0.0005870949,0.00006376605,0.006395949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421631,"threshold_uncertainty_score":0.008101106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167267719633993,"score_gpt":0.2939911164463182,"score_spread":0.2823184392499783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}