{"id":"W3118550692","doi":"10.1016/j.ophtha.2020.12.012","title":"Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset","year":2021,"lang":"en","type":"article","venue":"Ophthalmology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Isaac Newton Trust; National Institutes of Health; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; National Eye Institute; Moorfields Eye Charity; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Medicine; Visual acuity; Ophthalmology; Optic neuropathy; Leber's hereditary optic neuropathy; Visual field; Retinal; Surgery; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000414157,0.0001726352,0.0006593204,0.0002301205,0.0002299555,0.000293618,0.000183436,0.0005491208,0.0008309112],"category_scores_gemma":[0.0007461118,0.00007325435,0.0003643333,0.0001630411,0.0002838779,0.0003131408,0.00009732651,0.000681462,0.0001085034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000332964,"about_ca_system_score_gemma":0.0003735092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120057,"about_ca_topic_score_gemma":0.001445635,"domain_scores_codex":[0.9998127,0.00005351784,0.00001379279,0.00003082705,0.00003219446,0.00005698433],"domain_scores_gemma":[0.9996444,0.0001304377,0.00008611975,0.00002856048,0.00002602178,0.00008443294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4765897,0.02960565,0.03549342,0.0004846975,0.00079637,0.001605224,0.0003857631,0.002649938,0.2149732,0.0006375957,0.0008696866,0.2359088],"study_design_scores_gemma":[0.03142148,0.5844884,0.3046228,0.000158392,0.001730202,0.002125731,0.0003092341,0.006461097,0.06420343,0.0005399674,0.003823416,0.0001158731],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997728,0.001514616,0.0000930453,0.00004759083,0.00002478303,0.00002191817,0.0000457797,0.000008526124,0.0005157203],"genre_scores_gemma":[0.9992649,0.0002718216,0.00004837173,0.00002759449,0.00002934789,0.00001492097,0.00006392001,0.000002187435,0.0002769656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120057,"threshold_uncertainty_score":0.002779722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506042492905118,"score_gpt":0.2634685325006825,"score_spread":0.2484081075716313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}