{"id":"W3118550692","doi":"10.1016/j.ophtha.2020.12.012","title":"Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset","year":2021,"lang":"en","type":"article","venue":"Ophthalmology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Isaac Newton Trust; National Institutes of Health; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; National Eye Institute; Moorfields Eye Charity; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Medicine; Visual acuity; Ophthalmology; Optic neuropathy; Leber's hereditary optic neuropathy; Visual field; Retinal; Surgery; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009644381,0.0001373335,0.000264483,0.00003387915,0.00003572617,0.000002675172,0.0000787734,0.0001555692,0.00008229899],"category_scores_gemma":[0.0001733396,0.0001269622,0.0000859935,0.00006580551,0.0001625146,0.000002173042,0.00005225443,0.00005745403,9.588008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003238881,"about_ca_system_score_gemma":0.0001054224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001989127,"about_ca_topic_score_gemma":0.000002947031,"domain_scores_codex":[0.9989691,0.0001925319,0.0002871312,0.0003480242,0.000049595,0.0001536417],"domain_scores_gemma":[0.9992869,0.00007030413,0.0001143197,0.000310949,0.0001240108,0.00009348714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009775676,0.0003678545,0.01584822,0.00004298174,0.0001198418,0.0003428291,0.000062758,0.0001173799,0.9721756,0.000117474,0.0003296343,0.0006997262],"study_design_scores_gemma":[0.008200103,0.004871392,0.178063,0.00002195877,0.0001328056,0.003663895,0.00006510498,0.0001101242,0.802739,0.0002991641,0.001469791,0.0003636409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973897,0.001250712,0.0001274898,0.0001058667,0.0003734069,0.0002837,0.0002360244,0.000004397973,0.0002286413],"genre_scores_gemma":[0.9970351,0.0001795647,0.001424716,0.00008261712,0.0001343644,0.00002604999,0.0006070968,0.00002044452,0.0004900409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1694366,"threshold_uncertainty_score":0.5177369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506042492905118,"score_gpt":0.2634685325006825,"score_spread":0.2484081075716313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}