{"id":"W3118588688","doi":"10.3389/fphys.2020.624129","title":"Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"hERG; Zebrafish; Long QT syndrome; Repolarization; Cardiac electrophysiology; Potassium channel; Sudden death; Biology; Neuroscience; QT interval; Computational biology; Medicine; Bioinformatics; Electrophysiology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001031729,0.0002529009,0.001482573,0.0001076904,0.00001028449,0.000002507819,0.0002059639,0.0004705682,0.000008328123],"category_scores_gemma":[0.00003848281,0.0002510392,0.0002300827,0.0001683438,0.0001733119,0.000002481318,0.0002190625,0.0000871329,1.207786e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000650724,"about_ca_system_score_gemma":0.0000990937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009829579,"about_ca_topic_score_gemma":0.000004791892,"domain_scores_codex":[0.9986339,0.0001366311,0.0005148457,0.0004418011,0.00006049238,0.0002123502],"domain_scores_gemma":[0.9992617,0.00001565161,0.0001859287,0.0004455091,0.00004786167,0.00004332377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001380595,0.0005138258,0.000652566,0.06016703,0.002130488,0.0001178823,0.0002103766,0.000756167,0.02598585,0.00008261005,0.005639918,0.9036052],"study_design_scores_gemma":[0.005335072,0.002257786,0.01492393,0.03106178,0.002990736,0.001317358,0.0007185581,0.006076708,0.02160136,0.002817776,0.9053947,0.005504258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01559344,0.9794802,0.004236364,0.000001420453,0.0003299754,0.0002321084,0.00006634137,0.000003872496,0.00005628752],"genre_scores_gemma":[0.04209395,0.9558011,0.001616208,0.000006261748,0.00003416323,0.00002030397,0.0003579312,0.00002972812,0.0000403158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8997548,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856621017913297,"score_gpt":0.301661893282768,"score_spread":0.2830956831036351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}