{"id":"W3118606650","doi":"10.1101/2020.04.22.055384","title":"Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretion","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health; Innovative Medicines Initiative; European Commission; Imperial College London; Diabetes UK; Human Islet Research Network; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust","keywords":"MFN1; MFN2; Internal medicine; Endocrinology; Incretin; Beta cell; Insulin; Carbohydrate metabolism; Islet; Biology; mitochondrial fusion; Chemistry; Diabetes mellitus; Type 2 diabetes; Medicine; Mitochondrial DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295787,0.000466613,0.0002948837,0.0002221667,0.0002181871,0.0003682897,0.0002778939,0.0004354109,0.002442766],"category_scores_gemma":[0.0001505282,0.0001775444,0.0001892969,0.00008744527,0.0004007538,0.0003185305,0.0002772025,0.0006592312,0.000416649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470058,"about_ca_system_score_gemma":0.0001399314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287752,"about_ca_topic_score_gemma":0.0006382175,"domain_scores_codex":[0.9998864,0.000009753383,0.00001285069,0.00003637567,0.00002860692,0.00002602783],"domain_scores_gemma":[0.9996248,0.00002285414,0.0001754414,0.00001963571,0.0000222517,0.0001349157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477851,0.00001100917,0.0001514087,0.00002073406,0.000003098452,0.00004083988,0.000005912488,0.0000201576,0.999118,0.00006649697,0.00003497687,0.0003795169],"study_design_scores_gemma":[0.00006264153,0.0002416432,0.01888094,0.00002180381,0.00002739024,0.0007421183,0.00006192426,0.0008798924,0.9744211,0.0001162955,0.00453314,0.000011233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938327,0.0008738344,0.002820667,0.0001598754,0.00004805906,0.00002395931,0.0008127,0.0001262477,0.00130195],"genre_scores_gemma":[0.9938175,0.0003718814,0.002104635,0.00009616079,0.00002229506,0.000056547,0.0006588039,0.00007177995,0.002800351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002442766,"threshold_uncertainty_score":0.008171916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087049481524228,"score_gpt":0.2268017077476546,"score_spread":0.2059312129324123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}