{"id":"W3118622903","doi":"10.1007/s00228-020-03078-6","title":"Blinding, pragmatism, and the PRECIS-2 tool for designing and assessing randomized trials","year":2021,"lang":"en","type":"article","venue":"European Journal of Clinical Pharmacology","topic":"Health Policy Implementation Science","field":"Health Professions","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Family Medicine; Western University","funders":"","keywords":"Blinding; Randomized controlled trial; Medicine; Research design; Pragmatism; Endpoint Determination; Clinical trial; Medical physics; Surgery; Internal medicine; Philosophy; Epistemology; Sociology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7389625,0.006358667,0.01422945,0.01099216,0.004708,0.008812633,0.004266996,0.01027012,0.014003],"category_scores_gemma":[0.8763026,0.007517164,0.01435429,0.007132669,0.01635544,0.01101658,0.00821033,0.01611903,0.002737956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008971936,"about_ca_system_score_gemma":0.02061098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001986691,"about_ca_topic_score_gemma":0.003465523,"domain_scores_codex":[0.09260327,0.8140245,0.06419124,0.0120851,0.01561156,0.001484353],"domain_scores_gemma":[0.04434152,0.8475541,0.02799132,0.06184693,0.01657769,0.001688279],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.09664389,0.002098782,0.02243017,0.0640618,0.04291885,0.0006830681,0.01101049,0.01793841,0.004836522,0.1882845,0.06227937,0.4868142],"study_design_scores_gemma":[0.11475,0.0170341,0.02651746,0.02469729,0.02891925,0.001928856,0.001573493,0.1563449,0.02193041,0.4812822,0.1227007,0.002321292],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01609072,0.00459189,0.8477784,0.008834149,0.005212571,0.1020078,0.002333982,0.005343025,0.007807561],"genre_scores_gemma":[0.06142545,0.0003292905,0.7628936,0.001756328,0.0003912745,0.1713759,0.0002755621,0.000472452,0.001080176],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2610375,"threshold_uncertainty_score":0.3219057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8050444084390438,"score_gpt":0.7576008687410295,"score_spread":0.04744353969801429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}