{"id":"W3118624973","doi":"10.3389/fbioe.2020.572356","title":"Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion","year":2021,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Misericordia Community Hospital; University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Chondrogenesis; Mesenchymal stem cell; In vivo; Calcification; In vitro; Cell biology; Pathology; Biology; Stem cell; Anatomy; Chemistry; Medicine; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004974295,0.0001052474,0.0004405528,0.0003601042,0.000009515585,0.000001411066,0.00002911144,0.0002268715,6.940003e-7],"category_scores_gemma":[0.000008843032,0.0000867765,0.00002081694,0.0002385196,0.0001338598,0.00002991106,0.00003716579,0.00009894485,7.839803e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000159593,"about_ca_system_score_gemma":0.00001210281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000341223,"about_ca_topic_score_gemma":0.00001537965,"domain_scores_codex":[0.9993595,0.00001583656,0.000260218,0.0001830068,0.00007326114,0.0001081638],"domain_scores_gemma":[0.9997424,0.00001173292,0.00007816346,0.0001192012,0.00002623199,0.00002230892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377163,0.00008138219,0.06003592,0.0004662276,0.00002262007,0.00001623135,0.0002567118,0.00003447864,0.9374505,0.00003425336,8.54114e-7,0.00146309],"study_design_scores_gemma":[0.002630464,0.0005016254,0.008259673,0.0006421498,0.00003252643,0.0000227482,0.001108557,0.0003545057,0.9863655,0.0000106068,0.000003981651,0.00006765665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926515,0.007011292,0.00008560796,0.00002655207,0.00004212397,0.0001598365,0.00001191426,0.000009381144,0.000001762657],"genre_scores_gemma":[0.9931545,0.002012716,0.004799357,8.516927e-7,0.000002535965,0.000005397196,0.000006550622,0.00000851546,0.000009550257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05177625,"threshold_uncertainty_score":0.3538643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008215983370717373,"score_gpt":0.2062093562701605,"score_spread":0.1979933728994432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}