{"id":"W3118624973","doi":"10.3389/fbioe.2020.572356","title":"Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion","year":2021,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Misericordia Community Hospital; University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Chondrogenesis; Mesenchymal stem cell; In vivo; Calcification; In vitro; Cell biology; Pathology; Biology; Stem cell; Anatomy; Chemistry; Medicine; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003611968,0.0004167622,0.0003591142,0.0002364902,0.0001609841,0.0002133405,0.0001970578,0.0001642417,0.0007457077],"category_scores_gemma":[0.0001863233,0.0001646379,0.000363894,0.0001993613,0.000265899,0.0001439156,0.0002865624,0.0003686413,0.0002767525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221202,"about_ca_system_score_gemma":0.0003419469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245989,"about_ca_topic_score_gemma":0.002239206,"domain_scores_codex":[0.9994689,0.00008812922,0.00008142844,0.00009991998,0.000193526,0.00006827565],"domain_scores_gemma":[0.9997115,0.00006100625,0.00006087548,0.00005397092,0.0000509037,0.00006176671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005850099,0.00002902975,0.0002079318,0.00002483815,0.000002652925,0.00003354096,0.00001713379,0.00001165707,0.9991038,0.00001233435,0.000008878855,0.0004897279],"study_design_scores_gemma":[0.000007863592,0.0005963432,0.006488467,0.000004860399,0.00001330728,0.0002314575,0.00003206603,0.0003171121,0.9914672,0.000008323465,0.0008305157,0.000002271942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920133,0.002368302,0.003448827,0.00004285525,0.00005674053,0.00008141165,0.0002019954,0.00006167214,0.001724854],"genre_scores_gemma":[0.9937748,0.0007269643,0.00286944,0.00003758112,0.00002144136,0.00009976394,0.0005279596,0.00001357447,0.001928575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245989,"threshold_uncertainty_score":0.002494633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008215983370717373,"score_gpt":0.2062093562701605,"score_spread":0.1979933728994432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}