{"id":"W3118628495","doi":"10.1016/j.ejmech.2020.113136","title":"Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Moiety; Chemistry; Stereochemistry; Docking (animal); Tubulin; Colchicine; Structure–activity relationship; Microtubule; Combinatorial chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172099,0.0003718876,0.0002723742,0.0002313915,0.0001532641,0.0001793531,0.0002693849,0.0002602326,0.001902719],"category_scores_gemma":[0.0001523616,0.0001649652,0.0001184014,0.000200749,0.0002544068,0.0002065954,0.0002088321,0.0003418798,0.00049745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003606039,"about_ca_system_score_gemma":0.0004750788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008618634,"about_ca_topic_score_gemma":0.002895114,"domain_scores_codex":[0.9998765,0.00003989488,0.00000757275,0.00001132956,0.00002481163,0.00003981662],"domain_scores_gemma":[0.9999377,0.00001059679,0.00001681724,0.000003576504,0.000007750131,0.00002366461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00117927,0.0001095573,0.0002971166,0.0003564879,0.00001796383,0.0003572358,0.0001149626,0.0008096135,0.9667525,0.002560152,0.001153981,0.02629113],"study_design_scores_gemma":[0.0006161455,0.005953279,0.005305791,0.00004958975,0.00005567162,0.0009791388,0.00007411151,0.002203353,0.9437805,0.0002421041,0.04070083,0.00003949015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.931872,0.03766279,0.01044931,0.0007856559,0.0005883242,0.0001875392,0.0006730118,0.0004515267,0.0173299],"genre_scores_gemma":[0.9680562,0.01635145,0.005672228,0.0002327438,0.00009476966,0.0001194259,0.0004282396,0.00002685709,0.009018006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001902719,"threshold_uncertainty_score":0.00636524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914215955735356,"score_gpt":0.2369089012752581,"score_spread":0.2177667417179046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}