{"id":"W3118628495","doi":"10.1016/j.ejmech.2020.113136","title":"Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Moiety; Chemistry; Stereochemistry; Docking (animal); Tubulin; Colchicine; Structure–activity relationship; Microtubule; Combinatorial chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002471469,0.0006574231,0.001011653,0.00005798704,0.0005102502,0.0002323152,0.0007745081,0.0001964945,0.003328888],"category_scores_gemma":[0.003627485,0.0004379319,0.0004538621,0.0003202441,0.0003175948,0.0002375059,0.0004816297,0.001398948,0.00006946413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308278,"about_ca_system_score_gemma":0.0003808316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002729038,"about_ca_topic_score_gemma":0.00000189171,"domain_scores_codex":[0.995662,0.0003743034,0.0014677,0.0007141592,0.0009964539,0.0007853967],"domain_scores_gemma":[0.9959721,0.0009075648,0.001358325,0.0005260264,0.0004066208,0.0008293947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003186535,0.0001825921,0.00426099,0.0002768537,0.0002399214,0.001948374,0.0004374477,0.00002171608,0.9739197,0.000007896933,0.01040437,0.007981433],"study_design_scores_gemma":[0.002224206,0.0001220645,0.001833433,0.001146114,0.0003133345,0.003261018,0.001998844,0.00008303829,0.9325,0.0001516963,0.05579258,0.0005736655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603004,0.006250993,0.00006379074,0.003325639,0.0002935106,0.00006987045,0.0000416197,0.00006227605,0.02959188],"genre_scores_gemma":[0.990161,0.001967141,0.0005228641,0.0009486285,0.003229496,0.000001642008,0.00004490947,0.00009163505,0.003032701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04538821,"threshold_uncertainty_score":0.9998072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914215955735356,"score_gpt":0.2369089012752581,"score_spread":0.2177667417179046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}