{"id":"W3118677701","doi":"10.1101/2021.01.04.425128","title":"Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection <i>in vitro</i> and <i>in vivo</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Decoy; In vivo; Fusion protein; Mutant; In vitro; Neutralization; Receptor; Peptide library; Biology; Virology; Molecular biology; Chemistry; Recombinant DNA; Gene; Peptide sequence; Biochemistry; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306164,0.0003760501,0.000322113,0.0001075401,0.00009218937,0.0001993914,0.0001653753,0.0002109848,0.0006384687],"category_scores_gemma":[0.0001023524,0.00009482127,0.0002181426,0.0000969876,0.0001497027,0.000132209,0.000104797,0.000395594,0.0002351383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573404,"about_ca_system_score_gemma":0.0001571447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005491433,"about_ca_topic_score_gemma":0.0007767914,"domain_scores_codex":[0.9998761,0.00002088057,0.000009481864,0.00002289615,0.00003194845,0.00003856196],"domain_scores_gemma":[0.9999424,0.0000114119,0.00001617466,0.000007915404,0.000006184219,0.0000158134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209687,0.00006381261,0.00006864235,0.00001999556,0.00000660611,0.00001508571,0.000004664961,0.0001178575,0.9988691,0.00003382004,0.00004617443,0.0006333467],"study_design_scores_gemma":[0.00002757633,0.0007567016,0.0008101162,0.000001522058,0.000008988587,0.000105002,0.000004986507,0.00123421,0.996407,0.000007448461,0.0006344198,0.000002095476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967789,0.0006205792,0.001699319,0.00003384448,0.00001848153,0.0000223756,0.0001766892,0.00007491838,0.0005748562],"genre_scores_gemma":[0.9962052,0.0003228209,0.001761673,0.00003336375,0.0000103935,0.00002257636,0.0005781102,0.00001697965,0.001048968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006384687,"threshold_uncertainty_score":0.002135873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013032131672141,"score_gpt":0.2725056394995121,"score_spread":0.2523753181827906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}