{"id":"W3118686664","doi":"10.1172/jci131698","title":"Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"PTEN; Biology; Tensin; DNA damage; Stem cell; Cell biology; Haematopoiesis; Hematopoietic stem cell; Genome instability; Senescence; Cancer research; PI3K/AKT/mTOR pathway; Genetics; Signal transduction; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003518698,0.0003282133,0.0002125168,0.0003667278,0.0001729572,0.0003915928,0.0002361887,0.0001967953,0.000622415],"category_scores_gemma":[0.0001706937,0.0001413287,0.0001398403,0.0001679678,0.0004702635,0.0003819089,0.0003731149,0.0002927375,0.0001166127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606516,"about_ca_system_score_gemma":0.0002289664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008337057,"about_ca_topic_score_gemma":0.0001868228,"domain_scores_codex":[0.999837,0.00002856151,0.00001568371,0.00003567997,0.00004289722,0.00004005826],"domain_scores_gemma":[0.9998829,0.0000133128,0.00004679287,0.00001220716,0.000007272377,0.00003740121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003543211,0.00003047129,0.001879019,0.00004234346,0.000008628518,0.0002506881,0.00002997214,0.0002052305,0.9922576,0.0007914923,0.00003702975,0.00411322],"study_design_scores_gemma":[0.00007462136,0.001139858,0.04469584,0.000009881544,0.00007010096,0.001569534,0.0001216246,0.003180393,0.9448278,0.001643346,0.002649252,0.00001781357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944079,0.001639582,0.002614059,0.0001289167,0.00001532835,0.00002134501,0.0001010389,0.00006553581,0.001006297],"genre_scores_gemma":[0.998076,0.000529908,0.0008455095,0.00002220665,0.000009291894,0.00001424676,0.0000563068,0.000005543715,0.0004409739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000622415,"threshold_uncertainty_score":0.002082229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06054323323607035,"score_gpt":0.3451578053508976,"score_spread":0.2846145721148272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}