{"id":"W3118711697","doi":"10.1200/jco.20.01055","title":"Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133)","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":824,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Atezolizumab; Medicine; Internal medicine; Lung cancer; Hazard ratio; Placebo; Carboplatin; Oncology; Etoposide; Interim analysis; Gastroenterology; Surgery; Clinical trial; Cancer; Chemotherapy; Pembrolizumab; Immunotherapy; Confidence interval; Pathology; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000913235,0.0002260068,0.002457977,0.000260619,0.00005819132,0.00001602419,0.00009039621,0.0002190657,0.0001382168],"category_scores_gemma":[0.0008104297,0.000138396,0.0002205681,0.0006027556,0.0004495656,0.00008717416,0.0001239003,0.000757672,2.015397e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155834,"about_ca_system_score_gemma":0.00143619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005688373,"about_ca_topic_score_gemma":0.002309302,"domain_scores_codex":[0.9967782,0.000478527,0.001445373,0.0003636763,0.0006044324,0.0003298016],"domain_scores_gemma":[0.9942303,0.00132006,0.001381674,0.0002422147,0.002388414,0.000437363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01448972,0.0007126959,0.9722599,0.0001431889,0.008307744,0.001246904,0.0001962541,0.000138426,0.0002528963,0.00001340691,0.0003907502,0.001848164],"study_design_scores_gemma":[0.01802074,0.006885488,0.9658987,0.0001775067,0.006972529,0.00002679709,0.0002443213,0.00057346,0.0002598549,0.000004509907,0.0007911802,0.0001449177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947345,0.002686,0.00003226438,0.001292471,0.000119839,0.0002759423,0.00005363185,0.000007258554,0.0007980717],"genre_scores_gemma":[0.9942281,0.003843591,0.000767523,0.0004302122,0.0001138374,0.000005144765,0.00002976813,0.00002479482,0.0005570564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006361155,"threshold_uncertainty_score":0.5643623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05157558275665592,"score_gpt":0.4224178008924977,"score_spread":0.3708422181358418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}