{"id":"W3118711961","doi":"10.1186/s13195-020-00745-9","title":"Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Autoimmunity; Immunology; Immunosuppression; Medicine; Neurodegeneration; Immunosenescence; Autoantibody; Epigenetics; Disease; Biology; Internal medicine; Immune system; Gene; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088934,0.0007867496,0.0004450572,0.0009685276,0.0002387652,0.000371007,0.0003258124,0.0004801519,0.001206391],"category_scores_gemma":[0.0001103178,0.0002177677,0.0004027614,0.0002542529,0.0003980681,0.0003143145,0.0002411452,0.001050736,0.0002707508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003548737,"about_ca_system_score_gemma":0.0002347286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000715573,"about_ca_topic_score_gemma":0.001721061,"domain_scores_codex":[0.9997546,0.00002591125,0.00002705227,0.00006535972,0.00004916805,0.00007785605],"domain_scores_gemma":[0.9994903,0.00004045767,0.0001822662,0.00004949661,0.00003650685,0.0002010628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008194832,0.0002643376,0.0008982731,0.00002722293,0.00001327703,0.0001248359,0.00004353225,0.00005295942,0.9962865,0.00006194643,0.00004739254,0.001360115],"study_design_scores_gemma":[0.0001458002,0.00439854,0.04382183,0.00003099169,0.0001258884,0.0006283507,0.0001359505,0.0009757447,0.9476307,0.000147557,0.001929467,0.00002911433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979594,0.0005595292,0.00037097,0.00004674219,0.00001958419,0.00002066123,0.0005137683,0.00007301197,0.0004361949],"genre_scores_gemma":[0.9941011,0.0006709615,0.001343013,0.000110954,0.00002571737,0.0001011832,0.0009395708,0.00006288339,0.00264462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206391,"threshold_uncertainty_score":0.00403583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06647213425398009,"score_gpt":0.387684609700037,"score_spread":0.3212124754460569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}