{"id":"W3118769206","doi":"10.1248/bpb.b20-00679","title":"Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis","year":2020,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Mitsubishi Tanabe Pharma Corporation","keywords":"Edaravone; Cationic liposome; Chemistry; Pharmacology; Reactive oxygen species; Oxidative stress; Viability assay; Toxicity; Cytotoxicity; Cationic polymerization; Biochemistry; Liposome; Apoptosis; Transfection; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082793,0.000542016,0.0004278965,0.0002629762,0.0001415672,0.0001707747,0.0002806888,0.0004410288,0.0008422089],"category_scores_gemma":[0.0002612169,0.0001688227,0.0003712141,0.0001381851,0.0002173869,0.0002754968,0.0002771473,0.0004284128,0.0001201218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302835,"about_ca_system_score_gemma":0.0003423749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003653536,"about_ca_topic_score_gemma":0.0003621959,"domain_scores_codex":[0.9998846,0.00002143289,0.0000140905,0.00001753305,0.00002029901,0.0000420357],"domain_scores_gemma":[0.9998844,0.00001996521,0.00002558962,0.00001052279,0.00003539936,0.00002415249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007812908,0.0001112605,0.0001317166,0.0001349106,0.00001601374,0.0001333002,0.00002809964,0.00008025535,0.9944612,0.00008881299,0.00003259588,0.004000661],"study_design_scores_gemma":[0.0001294704,0.00209982,0.001439849,0.00002070746,0.00003369349,0.0002422214,0.00003629201,0.0003997732,0.9936673,0.0000794654,0.001845359,0.000006098348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990889,0.005348396,0.002363513,0.0001311936,0.00007079874,0.00006872495,0.00007775336,0.00005202887,0.0009987885],"genre_scores_gemma":[0.9929442,0.003095957,0.002218333,0.00009405399,0.00002159338,0.00007841196,0.0001829204,0.000009447051,0.001355172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008422089,"threshold_uncertainty_score":0.002817512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686022177536641,"score_gpt":0.2849035187947953,"score_spread":0.2580432970194289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}