{"id":"W3118769206","doi":"10.1248/bpb.b20-00679","title":"Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis","year":2020,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Mitsubishi Tanabe Pharma Corporation","keywords":"Edaravone; Cationic liposome; Chemistry; Pharmacology; Reactive oxygen species; Oxidative stress; Viability assay; Toxicity; Cytotoxicity; Cationic polymerization; Biochemistry; Liposome; Apoptosis; Transfection; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249559,0.0001534237,0.0002115308,0.00001234327,0.00004884363,0.00001126403,0.00008893268,0.000158043,0.0001100392],"category_scores_gemma":[0.0003250695,0.000103308,0.00004945692,0.00005459441,0.0002586468,0.000001597529,0.0001438117,0.0001354944,0.00002140134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003075448,"about_ca_system_score_gemma":0.00001025829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004013202,"about_ca_topic_score_gemma":3.257563e-7,"domain_scores_codex":[0.9990571,0.0001990479,0.0001703804,0.0003452268,0.00006234083,0.0001659047],"domain_scores_gemma":[0.9995604,0.00009811129,0.0000542887,0.00006669504,0.00005123382,0.0001692858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001030594,0.00005345172,0.005012001,0.0000745424,0.00007682216,0.000001234376,0.00004528396,0.000002650597,0.9842649,0.00001697302,0.0004153959,0.00900622],"study_design_scores_gemma":[0.0008730553,0.002630032,0.002017067,0.0000253438,0.00002488279,0.000001706139,0.00004225077,0.00008935138,0.9770562,0.00001077353,0.0170568,0.0001725075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962609,0.001127393,0.0001947146,0.001731036,0.00002743809,0.0003187782,0.0000805767,0.000009128869,0.0002499807],"genre_scores_gemma":[0.9972748,0.001445602,0.00004918713,0.0009523045,0.0001286202,0.00003490363,0.00009608686,0.000005551,0.00001290605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01664141,"threshold_uncertainty_score":0.4212777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686022177536641,"score_gpt":0.2849035187947953,"score_spread":0.2580432970194289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}