{"id":"W3118777027","doi":"10.1007/978-3-030-51140-1_13","title":"Frontotemporal Lobar Degeneration TDP-43-Immunoreactive Pathological Subtypes: Clinical and Mechanistic Significance","year":2021,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Frontotemporal lobar degeneration; Pathological; Frontotemporal dementia; Pathology; Progressive supranuclear palsy; Molecular pathology; Clinical significance; Biology; Neuroscience; Dementia; Medicine; Disease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301014,0.0001544772,0.0004783067,0.00004845717,0.0000607258,0.000005860721,0.00005063551,0.0001689577,0.0001507107],"category_scores_gemma":[0.0003132928,0.0001032489,0.00002946395,0.0001143995,0.0008853325,0.0001054989,0.00009796929,0.0002750916,0.000004277198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005470755,"about_ca_system_score_gemma":0.00005103635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007927818,"about_ca_topic_score_gemma":0.00004191943,"domain_scores_codex":[0.9984927,0.0002525915,0.0003928335,0.0004999059,0.0001104929,0.0002514526],"domain_scores_gemma":[0.9993958,0.000190705,0.00006543803,0.0001509536,0.00005809093,0.0001390332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007892059,0.0003181228,0.1687142,0.00003059832,0.00002648344,0.000308872,0.0004171714,4.691877e-7,0.794067,0.004560679,0.00005624862,0.03071098],"study_design_scores_gemma":[0.02650003,0.02637179,0.7077168,0.001002192,0.0001683107,0.00158349,0.01440118,0.001151865,0.1729744,0.01544061,0.03142761,0.001261806],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505531,0.04642087,0.000308599,0.001295069,0.0002703377,0.0002007704,0.000004256534,0.0000185295,0.0009284239],"genre_scores_gemma":[0.9858524,0.01105909,0.00168761,0.0009032562,0.0002872608,0.00004287241,0.00007077736,0.000008809759,0.00008790156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6210926,"threshold_uncertainty_score":0.4210367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09359218009211945,"score_gpt":0.4381454842700188,"score_spread":0.3445533041778993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}