{"id":"W3118844433","doi":"","title":"15th GPCR Retreat (Canada) - Determination of signaling signature of 40 SNPs found in melatonin type 2 receptor: from ligand-bias signaling to mutation-bias signaling","year":2014,"lang":"en","type":"article","venue":"","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"","keywords":"Melatonin; Signal transduction; G protein-coupled receptor; Biology; Single-nucleotide polymorphism; Mutation; Receptor; Genetics; Cell biology; Neuroscience; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962572,0.0003477275,0.0002856715,0.0006328356,0.001031694,0.0005040413,0.0004467585,0.0007978118,0.006910135],"category_scores_gemma":[0.0008470269,0.0001406592,0.0007468659,0.0007713549,0.0003812147,0.0001419367,0.0003684981,0.0007063454,0.0008960842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001562475,"about_ca_system_score_gemma":0.001995245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3034284,"about_ca_topic_score_gemma":0.4828829,"domain_scores_codex":[0.9993737,0.00005247908,0.00005285463,0.0002274569,0.0001391911,0.0001543323],"domain_scores_gemma":[0.9994475,0.00009925418,0.0001209511,0.00004110605,0.0001208257,0.0001703774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00549401,0.0002873795,0.6790023,0.0002708391,0.0009507638,0.008324071,0.001705894,0.0009177411,0.2322544,0.002066193,0.01276009,0.05596633],"study_design_scores_gemma":[0.0001104545,0.0002075333,0.9660662,0.00008142045,0.0003057223,0.003336553,0.0005789552,0.0006886812,0.01080405,0.0002485509,0.01751999,0.0000518999],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837723,0.0007454422,0.000947095,0.0005583751,0.0001563547,0.00005401851,0.008128367,0.00007368471,0.00556429],"genre_scores_gemma":[0.9910722,0.0002229948,0.001077437,0.0005653384,0.0000178358,0.00003680087,0.002524932,0.0000663004,0.004416178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3034284,"threshold_uncertainty_score":0.6033245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03383937618489085,"score_gpt":0.2556795051777722,"score_spread":0.2218401289928813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}