{"id":"W3118855677","doi":"10.1093/ecco-jcc/jjab012","title":"Long-Term Efficacy and Safety of Ozanimod in Moderately to Severely Active Ulcerative Colitis: Results From the Open-Label Extension of the Randomized, Phase 2 TOUCHSTONE Study","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Medicine; Ulcerative colitis; Internal medicine; Discontinuation; Adverse effect; Placebo; Gastroenterology; Calprotectin; Surgery; Inflammatory bowel disease; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003214025,0.0004768062,0.001122114,0.000242414,0.0001996098,0.0005461586,0.0003536437,0.0006569721,0.001861081],"category_scores_gemma":[0.001944759,0.0002419512,0.001082691,0.000268195,0.0005094106,0.0006463326,0.000419102,0.0008984084,0.0002666604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266311,"about_ca_system_score_gemma":0.000401175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001807944,"about_ca_topic_score_gemma":0.0005653175,"domain_scores_codex":[0.998845,0.0007582027,0.00009855202,0.0001099413,0.0001126765,0.00007560535],"domain_scores_gemma":[0.9975606,0.000644783,0.0009963667,0.0002128362,0.0001487387,0.0004365296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8947251,0.01023914,0.02741946,0.0007270445,0.001451144,0.0001310109,0.0001637907,0.0005376916,0.0122258,0.00004661201,0.0004017504,0.05193155],"study_design_scores_gemma":[0.3470739,0.4966562,0.1483894,0.00009760959,0.001754085,0.0003899293,0.0001139046,0.0008010434,0.002586562,0.00009153635,0.002001015,0.00004486546],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997832,0.001260159,0.0001739206,0.00004749785,0.00001516441,0.0002201886,0.0002078407,0.00001055054,0.0002327608],"genre_scores_gemma":[0.9972923,0.0007467376,0.0004045153,0.0001568904,0.00005969227,0.0001865669,0.0006868468,0.00000492839,0.0004614384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003214025,"threshold_uncertainty_score":0.01699764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998046479650412,"score_gpt":0.3070387626728044,"score_spread":0.2870582978763003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}