{"id":"W3118855677","doi":"10.1093/ecco-jcc/jjab012","title":"Long-Term Efficacy and Safety of Ozanimod in Moderately to Severely Active Ulcerative Colitis: Results From the Open-Label Extension of the Randomized, Phase 2 TOUCHSTONE Study","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Medicine; Ulcerative colitis; Internal medicine; Discontinuation; Adverse effect; Placebo; Gastroenterology; Calprotectin; Surgery; Inflammatory bowel disease; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006385049,0.0001395207,0.0004788342,0.00002605641,0.0001001064,0.00005448695,0.000218348,0.00006892061,0.000009809405],"category_scores_gemma":[0.0006203781,0.00008830159,0.00007127287,0.00008661662,0.0001627561,0.00002054969,0.0003015028,0.0001407353,1.219245e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002009958,"about_ca_system_score_gemma":0.000307651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001135894,"about_ca_topic_score_gemma":0.0007761581,"domain_scores_codex":[0.998063,0.0006866509,0.0006820119,0.0002301951,0.0002016899,0.0001364074],"domain_scores_gemma":[0.9984613,0.0001953911,0.0004545266,0.0002771875,0.0005104859,0.0001011141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9869055,0.001265968,0.0004030796,0.00001674155,0.000375775,0.0004517804,0.002712145,0.00005787746,0.003746917,0.00009582598,0.0002000479,0.003768321],"study_design_scores_gemma":[0.1361579,0.0004455309,0.8515204,0.000195176,0.0001201168,0.00004776264,0.0008632898,0.00002807813,0.01036387,0.0001336576,0.00003136894,0.00009285034],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975824,0.0005138437,0.00006044761,0.0002807135,0.00007870999,0.0009674085,0.000356377,6.544303e-7,0.0001594363],"genre_scores_gemma":[0.999159,0.0003494864,0.00008775565,0.0002152485,0.0000691754,0.00001252989,0.00001137616,0.00001038265,0.00008500351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8511173,"threshold_uncertainty_score":0.3600834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998046479650412,"score_gpt":0.3070387626728044,"score_spread":0.2870582978763003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}