{"id":"W3118863409","doi":"10.1111/wrr.12889","title":"The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis","year":2021,"lang":"en","type":"review","venue":"Wound Repair and Regeneration","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Myofibroblast; Scleroderma (fungus); Phenotype; Mechanotransduction; Fibrosis; Medicine; Cell biology; Pathology; Immunology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000310721,0.0007297074,0.001099233,0.001965694,0.0002856457,0.001129894,0.0006004917,0.0009515383,0.004534896],"category_scores_gemma":[0.0005010131,0.0001797188,0.0003318976,0.00228674,0.0004111201,0.001771381,0.0007352764,0.001395142,0.002949149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500961,"about_ca_system_score_gemma":0.0007208019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005025719,"about_ca_topic_score_gemma":0.000905406,"domain_scores_codex":[0.9998899,0.00001821792,0.00001792994,0.00001944957,0.00004412504,0.00001047711],"domain_scores_gemma":[0.9998272,0.00008054879,0.00002546272,0.000005514746,0.00004313658,0.00001805612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005866861,0.00004568475,0.0001148252,0.01656739,0.00005699452,0.0002638008,0.00009297939,0.0002408422,0.00192521,0.003491163,0.03795773,0.9391846],"study_design_scores_gemma":[0.00001126302,0.00008438226,0.000713335,0.004890631,0.0000821854,0.002151342,0.0001185862,0.00006655189,0.0003873149,0.00315332,0.9883227,0.00001825847],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000792978,0.9985655,0.00008397103,0.0002625866,0.000220332,0.000002186415,0.00001149245,0.000006378137,0.0007683322],"genre_scores_gemma":[0.0004459687,0.9984951,0.000100205,0.0001796069,0.0001902696,0.000003035568,0.00001802173,0.000001325375,0.0005664692],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004534896,"threshold_uncertainty_score":0.01517075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03711531629054773,"score_gpt":0.2833507336086836,"score_spread":0.2462354173181358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}