{"id":"W3118868995","doi":"10.1016/j.jpsychires.2021.01.008","title":"Association between COMT methylation and response to treatment in children with ADHD","year":2021,"lang":"en","type":"article","venue":"Journal of Psychiatric Research","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"HEC Montréal; Douglas Mental Health University Institute; McGill University","funders":"Canadian Institutes of Health Research","keywords":"rs4680; DNA methylation; Methylation; Epigenetics; CpG site; Pharmacogenetics; Genetics; Genotype; Psychology; Oncology; Catechol-O-methyl transferase; Gene; Medicine; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00259094,0.00007450477,0.0002761967,0.0007742984,0.00006374535,0.0000398885,0.00004206142,0.0000761285,0.00005263946],"category_scores_gemma":[0.0008959209,0.00005609206,0.00005525924,0.001204287,0.00001348812,0.00009796427,0.00002079291,0.0004178052,0.00001272402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005787009,"about_ca_system_score_gemma":0.0005675677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007361369,"about_ca_topic_score_gemma":0.00004914689,"domain_scores_codex":[0.9977012,0.0007565416,0.0003184418,0.0001483402,0.0008711662,0.000204342],"domain_scores_gemma":[0.9983613,0.0005591838,0.0001534955,0.0001352028,0.0006339134,0.0001569445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001158929,0.0002640534,0.98832,0.00000716513,0.0002269008,0.00002729847,0.0004771268,0.0000200753,0.000986448,0.000004064264,0.0004535416,0.008054392],"study_design_scores_gemma":[0.003392492,0.001810833,0.9920529,0.0000355023,0.0001182483,0.000137183,0.001240602,0.000007162427,0.0001268221,0.00006419735,0.0009635141,0.00005054874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760776,0.0006131292,0.0001439401,0.02266888,0.00003417791,0.0002967853,0.000003575943,0.000003351404,0.0001585867],"genre_scores_gemma":[0.9962192,0.0001865017,0.002051675,0.00003419466,0.0002480783,0.000004931933,0.000004277981,0.0000125916,0.001238619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02263468,"threshold_uncertainty_score":0.2287368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0868825093534037,"score_gpt":0.4395966439368005,"score_spread":0.3527141345833968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}