{"id":"W3118873596","doi":"10.21203/rs.3.rs-135997/v1","title":"CSF total tau, plasma and CSF p tau 181 associated with structural changes in the early stage of Alzheimer's disease","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"White matter; Atrophy; Dementia; Biomarker; Neurodegeneration; Magnetic resonance imaging; Cerebrospinal fluid; Internal medicine; Disease; Psychology; Tau protein; Cohort; Pathology; Medicine; Alzheimer's disease; Oncology; Chemistry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004306942,0.0003571761,0.0003075518,0.0009362275,0.000213167,0.0005227716,0.0001278169,0.0003617847,0.002922609],"category_scores_gemma":[0.001363538,0.0001785273,0.0001502151,0.0004769365,0.0002524376,0.0002352888,0.0002275025,0.0003041699,0.0004644718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153125,"about_ca_system_score_gemma":0.0001472644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009201799,"about_ca_topic_score_gemma":0.0005085104,"domain_scores_codex":[0.9998978,0.00002518949,0.00001104752,0.00002846584,0.00002266852,0.00001471818],"domain_scores_gemma":[0.9994826,0.0001442397,0.0001619527,0.00004396157,0.00007880225,0.00008844627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003611513,0.0003334238,0.9483486,0.0001298666,0.0001941269,0.001770497,0.0004625779,0.0001895432,0.0280601,0.0001373207,0.0008631641,0.01589932],"study_design_scores_gemma":[0.00002285367,0.0002256439,0.9952912,0.000009032999,0.00004490597,0.001791385,0.0001309936,0.0002644271,0.001671818,0.0002532694,0.0002891134,0.000005260612],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985566,0.0004611084,0.0001954909,0.00003570153,0.00001291394,0.000005857144,0.0002524372,0.00001160345,0.0004683848],"genre_scores_gemma":[0.9986578,0.0001437827,0.0003036901,0.00001790483,0.00002278744,0.000007585756,0.0002461926,0.000005194521,0.0005949695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002922609,"threshold_uncertainty_score":0.009777069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045196637904969,"score_gpt":0.4023873440358232,"score_spread":0.2978676802453263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}