{"id":"W3118887409","doi":"10.1016/j.xpro.2020.100264","title":"An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"STAR Protocols","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Taiwan University; Toronto General Hospital Research Institute, University Health Network; National Institutes of Health; National Cancer Institute; National Taiwan University Hospital","keywords":"Induced pluripotent stem cell; Cytotoxic T cell; Virology; Immunotherapy; CD8; Antigen; Hepatitis B virus; Cancer immunotherapy; Adoptive cell transfer; Immunology; Biology; Cancer research; T cell; Medicine; Virus; Immune system; Embryonic stem cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007213413,0.0002305562,0.0004765764,0.00006630646,0.0001635811,0.0001153098,0.0002665794,0.0001311265,0.002970559],"category_scores_gemma":[0.00002261021,0.0001612769,0.0002089275,0.0002079095,0.0001230166,0.0001218877,0.00006730865,0.0001733456,0.00001615606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913188,"about_ca_system_score_gemma":0.0007384229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004486492,"about_ca_topic_score_gemma":0.00001022175,"domain_scores_codex":[0.9975637,0.0002784293,0.0005613905,0.0005097921,0.0006595773,0.0004270776],"domain_scores_gemma":[0.9978341,0.0001886654,0.0001839582,0.001041032,0.0005877299,0.0001644776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005437268,0.000521448,0.00011572,0.0001830133,0.0001292432,0.00001889182,0.0006677681,0.0002320435,0.9547979,0.00007017305,0.00118071,0.03664582],"study_design_scores_gemma":[0.01153019,0.001115693,0.0002158566,0.0001323442,0.000009114912,0.00000451849,0.0002854573,0.007544173,0.7904806,0.00007865653,0.1884647,0.0001387612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04324754,0.00003076584,0.004825127,0.0001761828,0.00005346688,0.9513659,0.000120907,0.00005547985,0.000124656],"genre_scores_gemma":[0.001874248,0.00001221952,0.01189315,0.0001154228,0.0006398615,0.9842395,0.00005714416,0.00006442922,0.001103973],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.187284,"threshold_uncertainty_score":0.9979408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221655969962696,"score_gpt":0.3892626040598666,"score_spread":0.267097007063597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}