{"id":"W3118905815","doi":"10.3390/cancers13010153","title":"Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Fondation du cancer du sein du Québec; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Cancer research; Gene silencing; Epithelial–mesenchymal transition; Macrophage polarization; Metastasis; Transcription factor; Mesenchymal stem cell; Cancer; Phenotype; Medicine; Cancer cell; Biology; Pathology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006315982,0.0001212015,0.0002091508,0.00003243429,0.00002825019,0.000007495,0.00007030629,0.0001020131,0.0000973612],"category_scores_gemma":[0.00004336166,0.0001103482,0.00005216564,0.0001197761,0.0001156675,0.000004302252,0.00004986492,0.00007408869,7.41346e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662803,"about_ca_system_score_gemma":0.0004176998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003735373,"about_ca_topic_score_gemma":0.0007037967,"domain_scores_codex":[0.9991599,0.00007373733,0.0002089697,0.0003044093,0.00009576121,0.0001571696],"domain_scores_gemma":[0.9994757,0.00001503338,0.0001960122,0.0001851905,0.00007562884,0.00005243923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002110152,0.00001896047,0.006728211,0.00005112142,0.00008629253,0.000005554306,0.0002332165,0.00410298,0.9726714,0.00002889163,0.001514752,0.01434758],"study_design_scores_gemma":[0.001371966,0.0002219719,0.0215829,0.0003208059,0.00004490531,0.000008756734,0.0002014905,0.0009328259,0.9680288,0.0002198855,0.006830763,0.0002349726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865097,0.01271047,0.0001262373,0.0001457722,0.0001027314,0.0001403001,0.00009631359,0.000004272907,0.0001642282],"genre_scores_gemma":[0.9963196,0.002826127,0.0002926733,0.0001895721,0.00004708915,0.00003234985,0.0001066435,0.0000119006,0.0001740248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01485469,"threshold_uncertainty_score":0.4499871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447593034105244,"score_gpt":0.3089331627642967,"score_spread":0.2944572324232443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}