{"id":"W3119003533","doi":"10.1016/j.bbrc.2020.12.091","title":"The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy","year":2021,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Mitacs; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; ALS Society of Canada; Heart and Stroke Foundation of Canada","keywords":"Autophagy; Biology; ULK1; Coronavirus; Proteases; Protein kinase domain; Virology; Cell biology; Betacoronavirus; Viral replication; Viral pathogenesis; Protein kinase A; Kinase; Virus; Genetics; Mutant; Medicine; Coronavirus disease 2019 (COVID-19); Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828998,0.0003152782,0.0002030625,0.0001035336,0.0001496272,0.0002410259,0.0001450938,0.0002548457,0.0008374817],"category_scores_gemma":[0.000135438,0.0001196704,0.000345282,0.000089753,0.0001546986,0.000208301,0.0001559245,0.0004029594,0.0003137235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002999439,"about_ca_system_score_gemma":0.0001911163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278289,"about_ca_topic_score_gemma":0.0004446486,"domain_scores_codex":[0.9998788,0.00002290503,0.00001558913,0.00002979283,0.00002053347,0.00003242584],"domain_scores_gemma":[0.9999347,0.00001302109,0.00002418397,0.000008425156,0.000007414646,0.00001231243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385866,0.00002247691,0.0004577388,0.00005507392,0.000007422483,0.0000906427,0.00001232785,0.00007885395,0.9980051,0.00008539303,0.00004121307,0.001005237],"study_design_scores_gemma":[0.000009665906,0.0001720842,0.004190808,0.00000509239,0.000006127967,0.0004918936,0.0000180875,0.0007739044,0.9931513,0.00007116506,0.001106631,0.000003217085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942724,0.001987455,0.002336743,0.0001130991,0.00002250219,0.0000199013,0.0003131447,0.00003678726,0.0008979001],"genre_scores_gemma":[0.9945047,0.0006949445,0.003001036,0.00007210885,0.000005909755,0.00001907905,0.0005634397,0.000008386599,0.001130339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008374817,"threshold_uncertainty_score":0.002801657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09408823627924245,"score_gpt":0.4262761923495985,"score_spread":0.332187956070356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}