{"id":"W3119014572","doi":"10.1002/jev2.12046","title":"Dissemination of <i>Mycobacterium tuberculosis</i> is associated to a <i>SIGLEC1</i> null variant that limits antigen exchange via trafficking extracellular vesicles","year":2021,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Wellcome Trust","keywords":"Mycobacterium tuberculosis; Biology; Null allele; Extracellular; Null cell; Antigen; Immunology; Tuberculosis; Microbiology; Gene; Allele; Cell biology; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001092072,0.0003656355,0.0008096528,0.0003132265,0.0002220273,0.00007958327,0.0003825698,0.000352527,0.001160095],"category_scores_gemma":[0.0003581889,0.0003253726,0.0004642749,0.0004936492,0.0001273566,0.0003195642,0.0000986361,0.0004951732,0.0002004276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511783,"about_ca_system_score_gemma":0.0002079139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002784364,"about_ca_topic_score_gemma":0.00002774125,"domain_scores_codex":[0.996911,0.0006159887,0.001023366,0.0004128639,0.0003442801,0.0006924549],"domain_scores_gemma":[0.9975172,0.0004692024,0.0007911102,0.0004049353,0.000629728,0.0001877785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002623082,0.001507355,0.003070143,0.00008421038,0.0009712741,0.001146781,0.002347911,0.00001471305,0.9688319,0.0000383013,0.004796277,0.01692885],"study_design_scores_gemma":[0.001532733,0.0006524026,0.01104174,0.0005614737,0.0002715302,0.0008579327,0.0006055931,0.00001828183,0.9704999,0.00008716357,0.01355729,0.0003139959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9322378,0.06292851,0.002458452,0.001281091,0.0004556688,0.0002986748,0.0001709107,0.00002932213,0.0001395825],"genre_scores_gemma":[0.9955696,0.00196814,0.0006569809,0.00008887209,0.0000992023,0.00001059438,0.000145334,0.0000526606,0.001408637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06333178,"threshold_uncertainty_score":0.9999198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829388823237029,"score_gpt":0.2578404205263707,"score_spread":0.2395465322940004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}