{"id":"W3119084223","doi":"10.1002/cac2.12128","title":"Lung adenocarcinoma patients with novel ALK fusion variants and their clinical responses to ALK inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancer Communications","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Crizotinib; Anaplastic lymphoma kinase; Ceritinib; Lung cancer; Medicine; ALK inhibitor; ROS1; Adenocarcinoma; Alectinib; Targeted therapy; Internal medicine; Oncology; Cancer research; Pathology; Cancer; Malignant pleural effusion","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007834313,0.0003729288,0.0008138085,0.0005468136,0.0004623241,0.0008007502,0.0006079974,0.002043375,0.002096827],"category_scores_gemma":[0.003445253,0.0002360802,0.0003404889,0.0004310444,0.0004482045,0.001355245,0.0004260405,0.002173295,0.0007361622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309414,"about_ca_system_score_gemma":0.0002290035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003630016,"about_ca_topic_score_gemma":0.000657502,"domain_scores_codex":[0.999616,0.0000774358,0.00007403082,0.00007380018,0.00009394776,0.00006481292],"domain_scores_gemma":[0.9985182,0.0005567733,0.0002581884,0.00005867935,0.0003398497,0.0002683268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002928324,0.000340458,0.2388475,0.001263235,0.0003398224,0.2752137,0.001070023,0.0004661091,0.006167312,0.001507849,0.3544483,0.1174074],"study_design_scores_gemma":[0.0004339027,0.001092611,0.1772352,0.0009953006,0.0006167892,0.472638,0.0017454,0.004342509,0.003933514,0.001757536,0.3349799,0.0002293181],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4777957,0.1094062,0.005070653,0.3150488,0.07447542,0.000308762,0.002790205,0.000480138,0.01462409],"genre_scores_gemma":[0.8230903,0.02988938,0.002310313,0.04266412,0.09427033,0.00008578149,0.0008728584,0.00008293043,0.006734008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002096827,"threshold_uncertainty_score":0.007014573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04499332222414623,"score_gpt":0.3792784071182471,"score_spread":0.3342850848941008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}