{"id":"W3119084223","doi":"10.1002/cac2.12128","title":"Lung adenocarcinoma patients with novel ALK fusion variants and their clinical responses to ALK inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancer Communications","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Crizotinib; Anaplastic lymphoma kinase; Ceritinib; Lung cancer; Medicine; ALK inhibitor; ROS1; Adenocarcinoma; Alectinib; Targeted therapy; Internal medicine; Oncology; Cancer research; Pathology; Cancer; Malignant pleural effusion","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010661,0.0001453633,0.000251337,0.00007452358,0.00031426,0.00003435554,0.0001670599,0.00006813619,0.00006632959],"category_scores_gemma":[0.0001332109,0.0001078465,0.00005452003,0.0003427532,0.0001622911,0.0000936459,0.0002697011,0.0001944662,0.000006207174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660263,"about_ca_system_score_gemma":0.0006166318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001622182,"about_ca_topic_score_gemma":0.0003410239,"domain_scores_codex":[0.9989955,0.0001024969,0.0003008562,0.0002946548,0.0001345022,0.000171971],"domain_scores_gemma":[0.9977634,0.000273793,0.00008660478,0.001241947,0.0004047912,0.0002294439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002762905,0.0009038295,0.9714231,0.00002753568,0.0003625774,0.000004975068,0.001957554,0.000004440233,0.0005041186,0.0004333801,0.002873056,0.02122909],"study_design_scores_gemma":[0.003110313,0.0002178406,0.9517696,0.0003042733,0.00031446,0.00001205584,0.0005023933,0.000107698,0.0001750953,0.00002230136,0.04332166,0.0001423118],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688347,0.007175147,0.000847398,0.01799539,0.0002452489,0.0008919874,0.0004515004,0.00006803458,0.003490568],"genre_scores_gemma":[0.9903066,0.001100416,0.005276659,0.001775849,0.00007820554,0.0002208823,0.0002386543,0.00002846394,0.0009742313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04044861,"threshold_uncertainty_score":0.4397852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04499332222414623,"score_gpt":0.3792784071182471,"score_spread":0.3342850848941008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}