{"id":"W3119089372","doi":"10.1158/1078-0432.ccr-20-4576","title":"A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; Victoria University; ZonMw; Worldwide Cancer Research","keywords":"Chronic lymphocytic leukemia; Cancer research; T cell; Antigen; Immunotherapy; Leukemia; Immunology; Antibody; Population; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702226,0.0003108211,0.0002770815,0.0001880531,0.0001801297,0.0002344631,0.0001414204,0.0002040827,0.001029333],"category_scores_gemma":[0.0001331915,0.0001029888,0.0001388849,0.0001317414,0.0001750405,0.0001326695,0.0001973754,0.0003083881,0.0002249009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004164073,"about_ca_system_score_gemma":0.0001839438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009339188,"about_ca_topic_score_gemma":0.001024258,"domain_scores_codex":[0.9998978,0.00001757993,0.000006927407,0.0000224967,0.00001747176,0.0000376861],"domain_scores_gemma":[0.9999419,0.00001257726,0.00001154139,0.00000671161,0.000005794715,0.00002133692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004511787,0.001415759,0.02287871,0.0001303186,0.00003200909,0.0004884861,0.0002073609,0.0005668774,0.9460847,0.0000800982,0.0004113629,0.02319246],"study_design_scores_gemma":[0.002331374,0.06507714,0.2423185,0.0000495293,0.0001938879,0.007478152,0.0005139323,0.005751448,0.6646414,0.0001913762,0.01142356,0.00002970436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994469,0.000184396,0.00009399487,0.000009416682,0.000002616874,0.00001165766,0.00003594733,0.000008099507,0.0002067864],"genre_scores_gemma":[0.9993097,0.0001043762,0.0001093689,0.00001964019,0.000005078442,0.00001645023,0.0001394111,0.000001875738,0.0002940878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029333,"threshold_uncertainty_score":0.00344348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2790387879152554,"score_gpt":0.531461172556048,"score_spread":0.2524223846407925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}