{"id":"W3119219373","doi":"10.1016/j.biopsycho.2021.108021","title":"Internalizing symptoms associate with the pace of epigenetic aging in childhood","year":2021,"lang":"en","type":"article","venue":"Biological Psychology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Canadian Institute for Advanced Research; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"Jacobs Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Koninklijke Nederlandse Akademie van Wetenschappen; Foundation for the National Institutes of Health","keywords":"Epigenetics; Cohort; Longitudinal study; Psychology; Late childhood; DNA methylation; Twin study; Early childhood; Medicine; Psychiatry; Developmental psychology; Internal medicine; Biology; Genetics; Heritability","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003354276,0.0002139175,0.0001635436,0.0005202118,0.0001684787,0.0003544826,0.0001238339,0.0001774796,0.0009813532],"category_scores_gemma":[0.001244353,0.0001795326,0.0002434772,0.0004744057,0.0001957262,0.0001937648,0.0003342072,0.0003459169,0.0001059337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204172,"about_ca_system_score_gemma":0.0002047061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003597508,"about_ca_topic_score_gemma":0.007467225,"domain_scores_codex":[0.9998449,0.0000339291,0.00001291064,0.00004790715,0.00002824573,0.00003205429],"domain_scores_gemma":[0.9990727,0.00009900609,0.0005922145,0.00006723261,0.00007669753,0.00009215304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004557165,0.00001446515,0.9957299,0.000006246851,0.00002502492,0.00004812041,0.0001202491,0.00002712282,0.001738367,0.00002383937,0.00002538652,0.002195725],"study_design_scores_gemma":[2.020646e-7,0.00001206595,0.9997583,8.673524e-7,0.000003531342,0.00003428223,0.00003089454,0.00001429609,0.000110529,0.000007088464,0.00002735505,5.166801e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993623,0.0001609311,0.0001148647,0.00001606198,0.000002179539,0.000002478472,0.0001170904,0.000004243205,0.0002199665],"genre_scores_gemma":[0.9993278,0.0001370845,0.0001523123,0.000007547137,0.000002872082,0.000002690789,0.0001630769,0.000002095419,0.0002046927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003597508,"threshold_uncertainty_score":0.007153094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802920207579274,"score_gpt":0.3021044552621135,"score_spread":0.2840752531863208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}