{"id":"W3119297022","doi":"10.1016/j.ejca.2020.10.032","title":"A phase 1b trial of selinexor, a first-in-class selective inhibitor of nuclear export (SINE), in combination with doxorubicin in patients with advanced soft tissue sarcomas (STS)","year":2021,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"University Health Network","keywords":"Neutropenia; Medicine; Febrile neutropenia; Internal medicine; Doxorubicin; Tolerability; Adverse effect; Gastroenterology; Vomiting; Phases of clinical research; Surgery; Chemotherapy; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024184,0.001651392,0.002106531,0.0004645289,0.000337011,0.0009305408,0.0006880016,0.001222397,0.005385763],"category_scores_gemma":[0.0007550825,0.0004812847,0.001179962,0.00037479,0.0008782956,0.000930028,0.0003740767,0.003213805,0.001188285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007233904,"about_ca_system_score_gemma":0.0008396799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007998682,"about_ca_topic_score_gemma":0.003134463,"domain_scores_codex":[0.9997928,0.00008394844,0.000008588895,0.00004012467,0.00001522902,0.00005932439],"domain_scores_gemma":[0.9995463,0.0000901698,0.00006136697,0.00003765876,0.00002441636,0.000240023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.664988,0.03914856,0.005844655,0.001602697,0.001921268,0.0003834,0.0006223771,0.005756871,0.06469588,0.001197838,0.01312374,0.2007146],"study_design_scores_gemma":[0.6675848,0.3050624,0.01169423,0.00007352962,0.0004984532,0.0005483424,0.0001416786,0.001974799,0.005524782,0.0006388526,0.006209615,0.00004857264],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986626,0.00320218,0.0009405695,0.00139207,0.0002641758,0.001643134,0.002122266,0.0002417864,0.003567857],"genre_scores_gemma":[0.9789132,0.003384758,0.002036502,0.001515809,0.0001556501,0.001828539,0.005406868,0.00008198687,0.006676601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005385763,"threshold_uncertainty_score":0.01801717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00421235592845011,"score_gpt":0.2316386944021195,"score_spread":0.2274263384736694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}