{"id":"W3119316674","doi":"10.3390/medicina57010064","title":"Update on Gene Therapy Clinical Trials for Choroideremia and Potential Experimental Therapies","year":2021,"lang":"en","type":"review","venue":"Medicina","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Choroideremia; Medicine; Clinical trial; Diabetic retinopathy; Ophthalmology; Visual acuity; Internal medicine; Diabetes mellitus; Pediatrics; Retinal","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006874555,0.0009290613,0.003230334,0.004557314,0.0004445272,0.003131896,0.001655572,0.003619176,0.008108255],"category_scores_gemma":[0.01214697,0.0005251191,0.002317997,0.004623256,0.0007100834,0.003440998,0.001153632,0.003224287,0.002037066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001886462,"about_ca_system_score_gemma":0.005088015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617372,"about_ca_topic_score_gemma":0.004611229,"domain_scores_codex":[0.9964823,0.001137366,0.001145256,0.0001648578,0.000948009,0.0001221614],"domain_scores_gemma":[0.9839678,0.01039701,0.002113107,0.0002208891,0.002917735,0.0003833122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006797512,0.000119346,0.000333986,0.1573502,0.0006902348,0.0002965892,0.0001635107,0.0001901673,0.001662141,0.002564535,0.09216073,0.7437888],"study_design_scores_gemma":[0.0004161554,0.0004773869,0.001136948,0.1250693,0.002410982,0.000679331,0.000129693,0.00007446978,0.0003798134,0.001513554,0.8676825,0.00002984758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002363387,0.9922616,0.0001979328,0.003383976,0.001561677,0.00008386862,0.0001901104,0.00002604365,0.002058495],"genre_scores_gemma":[0.001335957,0.9895669,0.0008384347,0.005756789,0.001176608,0.0001624729,0.0003473641,0.00001181646,0.0008036298],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008108255,"threshold_uncertainty_score":0.03635657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1798071944074616,"score_gpt":0.4765714075519575,"score_spread":0.2967642131444959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}