{"id":"W3119316674","doi":"10.3390/medicina57010064","title":"Update on Gene Therapy Clinical Trials for Choroideremia and Potential Experimental Therapies","year":2021,"lang":"en","type":"review","venue":"Medicina","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Choroideremia; Medicine; Clinical trial; Diabetic retinopathy; Ophthalmology; Visual acuity; Internal medicine; Diabetes mellitus; Pediatrics; Retinal","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001658984,0.0003467536,0.001477992,0.0000457724,0.00007652421,0.00003327413,0.0001665974,0.0004217078,0.00006942567],"category_scores_gemma":[0.0003536574,0.0002329626,0.0005949408,0.00004308062,0.0001174649,0.000001575078,0.00006340403,0.0001489586,0.000005125347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001021465,"about_ca_system_score_gemma":0.0002457933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001418862,"about_ca_topic_score_gemma":4.388077e-7,"domain_scores_codex":[0.9977059,0.0005510767,0.0008014529,0.0005659959,0.0001586943,0.000216863],"domain_scores_gemma":[0.99914,0.0001341709,0.0003086442,0.0002741317,0.00004238878,0.000100718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001571138,0.00008298666,0.00000618857,0.0002727491,0.0004616552,0.00000704281,0.00002399977,3.786193e-8,0.0005092916,0.00002267732,0.01222925,0.986227],"study_design_scores_gemma":[0.001460295,0.0006095177,0.000008394007,0.0006098169,0.0001545632,0.00001966703,0.00007380317,4.461077e-7,0.001040951,0.00001790754,0.9957362,0.0002683926],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001854533,0.9959747,0.0001934729,0.0001330818,0.0007347033,0.0009199701,0.00002546607,0.000008087358,0.0001559555],"genre_scores_gemma":[0.0003899825,0.9958153,0.0003688768,0.000550851,0.001132505,0.0001251071,0.001192919,0.00004750332,0.000376986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9859586,"threshold_uncertainty_score":0.949994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1798071944074616,"score_gpt":0.4765714075519575,"score_spread":0.2967642131444959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}