{"id":"W3119354482","doi":"10.1071/rdv33n2ab70","title":"70 Energy metabolites induce differential DNA methylation levels and transcription in trophectoderm and inner cell mass","year":2021,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"","keywords":"Blastocyst; Inner cell mass; Biology; DNA methylation; Methylation; Andrology; Embryo; Embryo culture; DNA demethylation; Molecular biology; Epigenetics; Gene expression; Embryogenesis; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629256,0.0001364788,0.0001531983,0.00005953319,0.00009918651,0.00004275303,0.00002255683,0.0001309399,0.00001199625],"category_scores_gemma":[0.00006169864,0.0001373856,0.00001847876,0.00009279945,0.00004487719,0.0000150683,0.00004275392,0.00006574007,2.837548e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001623333,"about_ca_system_score_gemma":0.00005739391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001908479,"about_ca_topic_score_gemma":0.00006120981,"domain_scores_codex":[0.9987167,0.0001318407,0.0002808396,0.0006233967,0.0001091045,0.0001381213],"domain_scores_gemma":[0.999602,0.00000860718,0.00005522305,0.0001816342,0.00009073372,0.00006175685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007523118,0.0000557961,0.004810833,0.00003912145,0.00001590911,6.428256e-7,0.0002797234,0.00001258994,0.9505273,0.00002965086,0.000001827138,0.04415143],"study_design_scores_gemma":[0.0003309718,0.00002072617,0.3453817,0.000004609542,0.000008450005,0.000001554109,0.00006264845,0.0000276398,0.6499775,0.0003562377,0.00372314,0.0001048328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804798,0.009532795,0.00950855,0.0001753714,0.0001334294,0.00008900095,0.000003602592,0.000007800786,0.00006969453],"genre_scores_gemma":[0.9962826,0.001128015,0.002083957,0.00002599361,0.00005693432,0.00001711136,0.0001010061,0.00000940869,0.0002949583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3405709,"threshold_uncertainty_score":0.5602422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217222427287089,"score_gpt":0.2365756018361755,"score_spread":0.2148533591074666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}