{"id":"W3119354482","doi":"10.1071/rdv33n2ab70","title":"70 Energy metabolites induce differential DNA methylation levels and transcription in trophectoderm and inner cell mass","year":2021,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"","keywords":"Blastocyst; Inner cell mass; Biology; DNA methylation; Methylation; Andrology; Embryo; Embryo culture; DNA demethylation; Molecular biology; Epigenetics; Gene expression; Embryogenesis; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008276223,0.0002194333,0.0002173943,0.0003014854,0.0001226714,0.0003561214,0.00009170442,0.0002221904,0.002444114],"category_scores_gemma":[0.00009956516,0.0001839701,0.0002636005,0.0001833159,0.0001799432,0.0001274938,0.0003429206,0.0003570054,0.0004653838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003157712,"about_ca_system_score_gemma":0.000174299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001745523,"about_ca_topic_score_gemma":0.002461661,"domain_scores_codex":[0.9998565,0.00001775202,0.00001284903,0.00004346598,0.00003784979,0.00003149826],"domain_scores_gemma":[0.9999336,0.00001139971,0.00001929842,0.000005524429,0.00001164227,0.00001844301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001294552,0.000008702622,0.0004987269,0.00003441708,0.000006670362,0.00003992885,0.00002777259,0.00001661827,0.9978422,0.0000473751,0.00005114796,0.001296988],"study_design_scores_gemma":[0.00002546851,0.0003740886,0.10116,0.0000364055,0.00004790901,0.0003427943,0.0001823239,0.0005030588,0.887453,0.0001307114,0.009730486,0.00001374744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853534,0.004573128,0.002429293,0.0001334605,0.00004692712,0.00003478678,0.001616522,0.00008035395,0.00573204],"genre_scores_gemma":[0.9813199,0.002282905,0.002069034,0.0001416074,0.00001249375,0.00007000747,0.002856424,0.00004408306,0.01120353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444114,"threshold_uncertainty_score":0.008176386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217222427287089,"score_gpt":0.2365756018361755,"score_spread":0.2148533591074666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}