{"id":"W3119400009","doi":"10.1038/s41467-020-20378-8","title":"BRD4-mediated repression of p53 is a target for combination therapy in AML","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Beatson Institute for Cancer Research; Howat Foundation; CHILDREN with CANCER UK; Constellation Pharmaceuticals; National Cancer Institute; Leuka; Cancer Research UK; Wellcome Trust","keywords":"Myeloid leukemia; Cancer research; BRD4; Psychological repression; Repressor; Mdm2; Activator (genetics); Suppressor; Biology; Apoptosis; Gene; Medicine; Genetics; Transcription factor; Gene expression; Bromodomain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514216,0.00006059823,0.00008733346,0.0000425649,0.00005833857,0.000007574849,0.000284308,0.0002392825,0.00001656327],"category_scores_gemma":[0.0004299116,0.0000596572,0.00005643948,0.0001807706,0.00004318553,0.000004853173,0.0001106155,0.0001723839,0.000001031829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009583703,"about_ca_system_score_gemma":0.00008302414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006109387,"about_ca_topic_score_gemma":0.00005440564,"domain_scores_codex":[0.999436,0.00009597674,0.0001851522,0.0001415442,0.00006951034,0.00007188491],"domain_scores_gemma":[0.9986882,0.0000472074,0.00009554312,0.0008666294,0.0002817602,0.00002066876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005546804,0.0004241385,0.004504491,0.00001129499,0.00002702984,1.57744e-7,0.0001325252,0.000004423669,0.9692655,0.003021204,0.01859165,0.003962173],"study_design_scores_gemma":[0.0008660464,0.00008392928,0.004216663,0.00002038776,0.000002486999,9.176657e-7,0.00004491257,0.0003227481,0.731264,0.0004656613,0.2626384,0.00007382391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9216789,0.04661397,0.00191145,0.02203635,0.0003897915,0.001392966,0.0003257845,0.00004032194,0.005610448],"genre_scores_gemma":[0.988226,0.002370766,0.006380345,0.0006810674,0.00002035331,0.00007484,0.001887306,0.000009120206,0.0003501764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2440468,"threshold_uncertainty_score":0.243275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702392506532876,"score_gpt":0.3136339725140772,"score_spread":0.2966100474487485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}