{"id":"W3119443482","doi":"10.1038/s41391-020-00311-2","title":"Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer","year":2021,"lang":"en","type":"article","venue":"Prostate Cancer and Prostatic Diseases","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; Departament d'Universitats, Recerca i Societat de la Informació; Xarxa de Bancs de Tumors de Catalunya; Cancer Council Tasmania; World Cancer Research Fund; Prostate Cancer Foundation; Medical Research Council; Canadian Cancer Society Research Institute; Manchester Biomedical Research Centre; National Institutes of Health; DOD Prostate Cancer Research Program; Hellenic Health Foundation; Instituto de Salud Carlos III; Tays; National Institute of Biomedical Imaging and Bioengineering; Cancer Council Victoria; University of Oxford; Deutsche Krebshilfe; National Health and Medical Research Council; Universiti Malaya; Health Technology Assessment Programme; Prostate Cancer Foundation of Australia; Vetenskapsrådet; KU Leuven; Canadian Institutes of Health Research; Bulgarian National Science Fund; Cancerfonden; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; National Institute for Health and Care Research; Gentofte Hospital; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Prostate Cancer Canada; Cancer Australia; Australian Government; Norges Forskningsråd; Swedish Cancer Foundation; Fundação para a Ciência e a Tecnologia; ZonMw; U.S. Department of Defense; Cancer Research UK; Cancer Research Coordinating Committee; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; Fundación Marqués de Valdecilla; Deutsches Krebsforschungszentrum; Cancer Research Institute; European Commission; Associazione Italiana per la Ricerca sul Cancro; Breast Cancer Research Foundation","keywords":"Medicine; Prostate cancer; Risk stratification; Single-nucleotide polymorphism; Oncology; Internal medicine; Polygenic risk score; Hazard ratio; Stratification (seeds); Cancer; Genotype; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006632735,0.000774461,0.0006039905,0.0005669738,0.0002587065,0.0006167523,0.0003635228,0.0005512396,0.001871013],"category_scores_gemma":[0.01113651,0.0002202881,0.001263977,0.0005296582,0.0003972576,0.0004623834,0.0008107329,0.0009742912,0.0002936664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863458,"about_ca_system_score_gemma":0.00039938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162333,"about_ca_topic_score_gemma":0.00120899,"domain_scores_codex":[0.9976488,0.001583529,0.0001002033,0.0003664431,0.0001818435,0.0001191358],"domain_scores_gemma":[0.9904193,0.006831019,0.00125546,0.0008741781,0.0002783618,0.0003416905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002804341,0.0002287005,0.9029366,0.0001012101,0.001354865,0.0001334529,0.0001014976,0.03657673,0.004097286,0.0003931903,0.0006627571,0.05060934],"study_design_scores_gemma":[0.0003101326,0.002389171,0.7474881,0.00006749861,0.001460093,0.0007568088,0.00006867725,0.2348064,0.005986585,0.004675854,0.001908371,0.00008231688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805056,0.0004929917,0.01730476,0.0002888177,0.00002024829,0.0000259452,0.0006044545,0.000122157,0.0006350134],"genre_scores_gemma":[0.9952757,0.00006335702,0.004082881,0.00004981033,0.00002515304,0.000009646776,0.0003768015,0.00001186433,0.0001047659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006632735,"threshold_uncertainty_score":0.03507763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663890770864722,"score_gpt":0.2930057873374157,"score_spread":0.2763668796287685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}