{"id":"W3119448726","doi":"10.1097/qai.0000000000002591","title":"Efficacy, Pharmacokinetics, and Safety Over 48 Weeks With Ibalizumab-Based Therapy in Treatment-Experienced Adults Infected With HIV-1: A Phase 2a Study","year":2021,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Theratechnologies (Canada)","funders":"","keywords":"Placebo; Medicine; Regimen; Pharmacokinetics; Viral load; Internal medicine; Gastroenterology; Human immunodeficiency virus (HIV); Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001890539,0.001336278,0.001917451,0.0003961643,0.0005128696,0.0008394815,0.0006539121,0.001415624,0.002062381],"category_scores_gemma":[0.001288125,0.0007417865,0.001055927,0.0003489787,0.0006893582,0.001043019,0.0002662653,0.002801521,0.0008051198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005566857,"about_ca_system_score_gemma":0.0006760577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005233907,"about_ca_topic_score_gemma":0.0007892091,"domain_scores_codex":[0.9992561,0.0003567511,0.00003624335,0.0001307443,0.00009986671,0.0001203409],"domain_scores_gemma":[0.9992211,0.0001421959,0.0002175689,0.00008176445,0.00004938687,0.0002879128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5887178,0.1719885,0.01141588,0.0005149061,0.001483687,0.0002523006,0.0004622174,0.002138616,0.08132114,0.0001338669,0.002646853,0.1389243],"study_design_scores_gemma":[0.2478029,0.6996055,0.04200174,0.00003529841,0.0005673945,0.0003014185,0.0000594898,0.001662278,0.006077558,0.0001269801,0.001701929,0.00005750803],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975395,0.0009371198,0.0002484063,0.000107146,0.00002920143,0.0003784142,0.0002747665,0.00004328836,0.0004419598],"genre_scores_gemma":[0.9950433,0.0008854043,0.0009104512,0.0003452657,0.0001328633,0.0009481972,0.0006845594,0.0000264382,0.001023492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062381,"threshold_uncertainty_score":0.009998262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427370124685731,"score_gpt":0.2958550487376346,"score_spread":0.2815813474907773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}