{"id":"W3119453605","doi":"10.3390/v13010109","title":"Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":334,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Context (archaeology); Viral entry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Lipid bilayer fusion; Function (biology); Computational biology; Messenger RNA; Receptor; Coronavirus; Spike Protein; Cell biology; Virology; Coronavirus disease 2019 (COVID-19); Genetics; Virus; Viral replication; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009486745,0.0002600603,0.001606602,0.0005399901,0.00002491481,0.0000153772,0.0002202298,0.0002211034,0.00001010297],"category_scores_gemma":[0.0005618436,0.0001634468,0.0001983535,0.001074452,0.0001073776,0.00005332813,0.00009111397,0.0005082282,0.00001290205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007593003,"about_ca_system_score_gemma":0.0007793703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009141994,"about_ca_topic_score_gemma":0.000673737,"domain_scores_codex":[0.9977706,0.0005432734,0.0007500505,0.0003286087,0.0003600665,0.0002473935],"domain_scores_gemma":[0.9984255,0.0007138649,0.0002140105,0.0005331978,0.00009953798,0.00001384064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004738631,0.001442037,0.002919571,0.03783897,0.0004614159,0.0005431806,0.0008561775,6.595506e-8,0.03916831,0.0009833523,0.001925545,0.9133875],"study_design_scores_gemma":[0.001201767,0.0003545665,0.0001003895,0.01399484,0.0002369878,0.00005302476,0.0003351316,0.000001747594,0.01741042,0.00003310725,0.9661322,0.0001458684],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01960603,0.977592,0.00005102001,0.00004973955,0.00003541446,0.002323513,0.00004034815,0.000009795123,0.0002921458],"genre_scores_gemma":[0.004469134,0.9851142,0.0002343288,0.009027792,0.0001396933,0.0008968033,0.00001293368,0.00007936655,0.00002570515],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9642066,"threshold_uncertainty_score":0.6665166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1929801414653831,"score_gpt":0.4238749767749961,"score_spread":0.230894835309613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}