{"id":"W3119453605","doi":"10.3390/v13010109","title":"Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":334,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Context (archaeology); Viral entry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Lipid bilayer fusion; Function (biology); Computational biology; Messenger RNA; Receptor; Coronavirus; Spike Protein; Cell biology; Virology; Coronavirus disease 2019 (COVID-19); Genetics; Virus; Viral replication; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538254,0.0003682762,0.0004301311,0.0003329615,0.0001572376,0.000462156,0.0002966337,0.0005069135,0.0004616958],"category_scores_gemma":[0.0001950736,0.0001440974,0.0003347921,0.0003626722,0.0004937907,0.0008797621,0.0002061113,0.0008601975,0.0003297542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039167,"about_ca_system_score_gemma":0.0004339344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003991396,"about_ca_topic_score_gemma":0.0004265231,"domain_scores_codex":[0.9999427,0.00001341569,0.000007653671,0.00001382508,0.00001256838,0.000009928797],"domain_scores_gemma":[0.999969,0.00001283189,0.000006305699,0.000001551151,0.000007247868,0.000002965676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000539294,0.0001230547,0.00109122,0.01565859,0.0001309522,0.001884167,0.001143008,0.01324438,0.2294376,0.2278113,0.01429419,0.4946422],"study_design_scores_gemma":[0.00002625742,0.0004537354,0.00123221,0.001090853,0.00009969508,0.001653651,0.0003675271,0.002344113,0.04815349,0.02636511,0.9181715,0.00004179558],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01606282,0.9706988,0.004539507,0.002278874,0.001078426,0.00002260415,0.00006252358,0.00002253297,0.005233995],"genre_scores_gemma":[0.05968847,0.93097,0.003234967,0.001035244,0.0006307766,0.0000362589,0.0001189181,0.000008541735,0.004276874],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0005069135,"threshold_uncertainty_score":0.003656149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1929801414653831,"score_gpt":0.4238749767749961,"score_spread":0.230894835309613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}