{"id":"W3119453960","doi":"10.1002/jlb.4a0220-114rr","title":"Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition","year":2021,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; Caspase; Apoptosis; Biology; Programmed cell death; Cell biology; Inflammation; Inhibitor of apoptosis; Intrinsic apoptosis; Cytotoxic T cell; XIAP; Caspase 8; Immunology; Cancer research; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788271,0.0003318875,0.0002243706,0.0001588374,0.00008985987,0.0001580074,0.0001254295,0.0002202264,0.000823141],"category_scores_gemma":[0.00009366315,0.0001015189,0.0002306798,0.0001272127,0.0001233221,0.0001151833,0.0001371679,0.0003353067,0.0002515525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414549,"about_ca_system_score_gemma":0.0001643585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001933374,"about_ca_topic_score_gemma":0.0002731932,"domain_scores_codex":[0.9998788,0.00003228071,0.0000150239,0.00001615417,0.00001993975,0.00003788981],"domain_scores_gemma":[0.999945,0.00001078899,0.00001455593,0.000008316198,0.000009725699,0.00001153227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005109453,0.00006199261,0.0001603805,0.00004523861,0.000005537775,0.00004678922,0.00002172001,0.00007200761,0.9969952,0.00009180904,0.00005252111,0.001935777],"study_design_scores_gemma":[0.00006044678,0.001191333,0.00128465,0.000004456315,0.000009941503,0.0002276424,0.00001203842,0.0004345391,0.994849,0.00002341112,0.001900086,0.000002356308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918864,0.003755791,0.002285086,0.00007444899,0.00003035885,0.0000896409,0.0001746168,0.00003332538,0.001670355],"genre_scores_gemma":[0.992023,0.001976474,0.003347827,0.00007382415,0.00001724226,0.0001268749,0.0003420485,0.00000853806,0.002084126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000823141,"threshold_uncertainty_score":0.002753675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009290740208780665,"score_gpt":0.2551295109232273,"score_spread":0.2458387707144467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}