{"id":"W3119454797","doi":"10.1016/j.mad.2021.111430","title":"Proteodynamics and aging of eukaryotic cells","year":2021,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Ministerstwo Edukacji i Nauki","keywords":"Proteome; Translation (biology); Computational biology; Posttranslational modification; Biology; Proteostasis; Cell biology; Bioinformatics; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073392,0.00008526962,0.0001264884,0.00002384615,0.00004017917,0.000007706471,0.00004330293,0.0000649198,0.000002419746],"category_scores_gemma":[0.00001634894,0.00008251765,0.00001652877,0.0000342023,0.00002835367,0.000002064079,0.0001443938,0.00003639183,1.40251e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003975378,"about_ca_system_score_gemma":0.00008891927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006623022,"about_ca_topic_score_gemma":0.00001510451,"domain_scores_codex":[0.9994576,0.0000161162,0.0001657544,0.0001795035,0.00007935108,0.0001016817],"domain_scores_gemma":[0.9997197,0.000004484377,0.00006848287,0.0001108802,0.00005971691,0.00003667049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009767265,0.00001323096,0.0002066407,0.000144053,0.00003321153,0.00001109291,0.0001222389,0.0000240109,0.9889802,0.000911144,0.000004066167,0.009540317],"study_design_scores_gemma":[0.0002273567,0.00005554442,0.002550191,0.00005066008,0.000007787002,0.00001788952,0.0001218332,0.0001028653,0.9947381,0.00179292,0.0002308709,0.0001039721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8581603,0.0005766028,0.1409433,0.00002662767,0.00006059029,0.00009428255,0.000004011123,0.000004264032,0.0001300206],"genre_scores_gemma":[0.8777534,0.0001314544,0.1218673,0.00004558709,0.000008606152,0.000003987085,0.00001938801,0.000007767107,0.0001625082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0195931,"threshold_uncertainty_score":0.3364972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004889794251366692,"score_gpt":0.2012800406040331,"score_spread":0.1963902463526664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}