{"id":"W3119463521","doi":"10.3899/jrheum.201088","title":"A Phase III Randomized Study of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, for Active Ankylosing Spondylitis","year":2021,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Astellas Pharma; Celgene; AstraZeneca; Amgen","keywords":"Apremilast; Medicine; Placebo; Ankylosing spondylitis; Adverse effect; Tolerability; Clinical endpoint; Internal medicine; Randomized controlled trial; Gastroenterology; Psoriatic arthritis; Arthritis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004034227,0.001942663,0.003822373,0.0005104073,0.000723936,0.001148234,0.001026478,0.001981741,0.006685745],"category_scores_gemma":[0.002768836,0.000967868,0.001303058,0.0005614008,0.001311296,0.001024575,0.0004354166,0.002905487,0.001107217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007588674,"about_ca_system_score_gemma":0.002282895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007215814,"about_ca_topic_score_gemma":0.00210032,"domain_scores_codex":[0.9988722,0.0006918291,0.00006136267,0.0001538978,0.0000935636,0.0001270806],"domain_scores_gemma":[0.99854,0.0003769099,0.0003292648,0.0001031826,0.0001307794,0.00051979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9709805,0.01072756,0.0005625125,0.0006261857,0.0006541435,0.00005554588,0.00004897449,0.0002959458,0.004069299,0.0001271962,0.00113752,0.01071474],"study_design_scores_gemma":[0.9602028,0.03819408,0.000624875,0.00001437623,0.000154334,0.00002307825,0.000007865236,0.0001797897,0.0001584913,0.00007085804,0.0003629432,0.000006509742],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453399,0.008478243,0.002934492,0.001614352,0.00150064,0.03301229,0.00308034,0.0003463055,0.00369347],"genre_scores_gemma":[0.9411613,0.005729035,0.006517101,0.003403148,0.001203035,0.03435009,0.002356644,0.00006487806,0.005214685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006685745,"threshold_uncertainty_score":0.02236599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484158030925407,"score_gpt":0.3284745368792122,"score_spread":0.3036329565699581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}