{"id":"W3119476937","doi":"10.1016/j.bonr.2021.100747","title":"Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab","year":2021,"lang":"en","type":"article","venue":"Bone Reports","topic":"Bone health and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Denosumab; RANKL; Medicine; Bone remodeling; Osteolysis; Internal medicine; N-terminal telopeptide; Endocrinology; Bone mineral; Osteoporosis; Osteopenia; Quantitative computed tomography; Oncology; Surgery; Osteocalcin; Alkaline phosphatase; Receptor; Activator (genetics); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633709,0.0009350187,0.0006839308,0.0005651526,0.0004844845,0.0002330634,0.0003289811,0.001059811,0.000879571],"category_scores_gemma":[0.0007548141,0.000191619,0.0005231276,0.0004501171,0.0004949763,0.0002341494,0.0003817256,0.0004612837,0.0002188484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003997581,"about_ca_system_score_gemma":0.0003015211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337524,"about_ca_topic_score_gemma":0.00228406,"domain_scores_codex":[0.9997184,0.00003926417,0.00003229191,0.00007898232,0.000064006,0.00006705527],"domain_scores_gemma":[0.999627,0.0000923241,0.0001265297,0.00002819238,0.00002956825,0.00009630623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0004725497,0.00008792374,0.02845019,0.0002328578,0.00008064866,0.9297624,0.0002046013,0.0003810345,0.02557049,0.0003029525,0.0003514832,0.01410282],"study_design_scores_gemma":[0.00006673678,0.0003068733,0.03308527,0.00002361215,0.00004228154,0.9627013,0.00007217081,0.0004083669,0.002000616,0.0001577807,0.001119862,0.00001510018],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847494,0.006839192,0.003072503,0.0006921081,0.00006984276,0.000117147,0.0001638094,0.0001345443,0.004161329],"genre_scores_gemma":[0.9972947,0.0007288281,0.0008372377,0.0002967756,0.00009560259,0.0000174225,0.00008189021,0.000009010454,0.0006384953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337524,"threshold_uncertainty_score":0.002942502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008390270523802831,"score_gpt":0.2475173939124988,"score_spread":0.239127123388696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}