{"id":"W3119493459","doi":"10.3390/pharmaceutics13010098","title":"Experimental and Computational Observations of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Liposome; Chemistry; Lipid bilayer; Biophysics; Porphyrin; Antigen; Bilayer; Cobalt; Internalization; Phospholipid; Biochemistry; Membrane; Biology; Organic chemistry; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794636,0.0003013176,0.0002772424,0.0003414942,0.0005029474,0.0003570871,0.0007095041,0.0006588064,0.003594703],"category_scores_gemma":[0.0004854132,0.0002231966,0.0003038047,0.000343246,0.0004235671,0.0003684091,0.0003280991,0.0004312334,0.0002196859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006091009,"about_ca_system_score_gemma":0.0005100257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005328158,"about_ca_topic_score_gemma":0.003424837,"domain_scores_codex":[0.9998922,0.000009399975,0.000005616066,0.00002233871,0.00002988218,0.000040477],"domain_scores_gemma":[0.9997951,0.00006691731,0.00003676749,0.00002534143,0.00005052287,0.00002541477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006744015,0.0003550574,0.01357224,0.0005151644,0.00008006147,0.0007817396,0.0002613324,0.8201982,0.147385,0.006151993,0.001444294,0.008580524],"study_design_scores_gemma":[0.00005503099,0.0001169602,0.004881186,0.00001622507,0.00001691356,0.0000562551,0.0001189003,0.9598638,0.03320789,0.0008729262,0.0007699666,0.00002385192],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917884,0.0001536866,0.002555471,0.0001590349,0.00001245916,0.00001430972,0.0007785927,0.0001212793,0.004416781],"genre_scores_gemma":[0.9982491,0.00007298651,0.001104707,0.0000138732,0.000002110181,0.00002014326,0.000280731,0.00001441373,0.0002420819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005328158,"threshold_uncertainty_score":0.01202548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03635565224387888,"score_gpt":0.3163466649322214,"score_spread":0.2799910126883425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}