{"id":"W3119493459","doi":"10.3390/pharmaceutics13010098","title":"Experimental and Computational Observations of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Liposome; Chemistry; Lipid bilayer; Biophysics; Porphyrin; Antigen; Bilayer; Cobalt; Internalization; Phospholipid; Biochemistry; Membrane; Biology; Organic chemistry; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009155672,0.00008819435,0.0001037244,0.00001992794,0.00005956654,0.00001745188,0.00007153037,0.00007092004,0.00004004002],"category_scores_gemma":[0.00003786901,0.0001002373,0.00005779998,0.00008137899,0.00003192604,0.000007298468,0.00008518546,0.000051969,0.000005291533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002727633,"about_ca_system_score_gemma":0.00009818222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005069554,"about_ca_topic_score_gemma":0.000002440492,"domain_scores_codex":[0.9993241,0.00004927509,0.0001935437,0.0001789852,0.000125602,0.0001284643],"domain_scores_gemma":[0.9995056,0.00002008418,0.0001129089,0.0001060657,0.0002144004,0.00004098056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000321798,0.00009020758,0.008540207,0.000009098273,0.0001224462,0.000001126864,0.0001131356,0.0002976604,0.9898354,0.00003447611,0.0006217084,0.0003023821],"study_design_scores_gemma":[0.0005879374,0.00006470089,0.008195451,0.000009277609,0.000021026,0.000006361092,0.0002263334,0.0005572781,0.9855081,0.00003066204,0.004686192,0.0001066462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953619,0.002733751,0.001241101,0.000129457,0.0001844398,0.00007402558,0.00005032452,0.000006374258,0.0002185957],"genre_scores_gemma":[0.9969187,0.0006351228,0.001377563,0.0003963305,0.00008624392,0.000006362681,0.0002527857,0.00000940053,0.0003174382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004327237,"threshold_uncertainty_score":0.408756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03635565224387888,"score_gpt":0.3163466649322214,"score_spread":0.2799910126883425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}