{"id":"W3119508578","doi":"10.3390/cancers13020261","title":"An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Horizon 2020 Framework Programme; Canada Research Chairs; European Regional Development Fund; Science Foundation Ireland","keywords":"Pancreatic cancer; Paracrine signalling; Unfolded protein response; Cancer research; Tumor microenvironment; Stromal cell; Cancer cell; Cancer; Biology; Medicine; Endoplasmic reticulum; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084306,0.0002622331,0.0005426143,0.00004198389,0.0000769139,0.00003677913,0.0002961203,0.0001817964,0.00003514769],"category_scores_gemma":[0.0001563437,0.0001861059,0.0002964235,0.0001423491,0.00005698291,0.00000259021,0.00004800169,0.0001197865,0.000001000543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775098,"about_ca_system_score_gemma":0.002464123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002940547,"about_ca_topic_score_gemma":0.0002294969,"domain_scores_codex":[0.9986576,0.0002140389,0.0002830538,0.0004609286,0.00009331739,0.0002910425],"domain_scores_gemma":[0.9990956,0.00005959655,0.0001486324,0.0005496242,0.00004988353,0.00009663428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007006167,0.00003411951,0.00003854005,0.005752853,0.0004415888,0.00002728208,0.0001060245,0.001449302,0.00237999,0.00007182833,0.001609407,0.9873884],"study_design_scores_gemma":[0.0003387152,0.00009141539,0.000006202411,0.003554068,0.0003246117,0.000003002064,0.0001813213,0.0001549339,0.0004342717,0.000008645319,0.9946182,0.000284593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006005837,0.9922905,0.00005159866,0.00003353073,0.000147813,0.001189014,0.0002252799,0.000006576613,0.0000498768],"genre_scores_gemma":[0.002532436,0.9923525,0.00005770121,0.00007336608,0.0002638439,0.003986278,0.0002561676,0.00005196961,0.0004256715],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930088,"threshold_uncertainty_score":0.7589179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391951564256695,"score_gpt":0.3480305188664268,"score_spread":0.3241110032238599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}