{"id":"W3119508578","doi":"10.3390/cancers13020261","title":"An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Horizon 2020 Framework Programme; Canada Research Chairs; European Regional Development Fund; Science Foundation Ireland","keywords":"Pancreatic cancer; Paracrine signalling; Unfolded protein response; Cancer research; Tumor microenvironment; Stromal cell; Cancer cell; Cancer; Biology; Medicine; Endoplasmic reticulum; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004201284,0.0006594933,0.001137547,0.001617497,0.000297867,0.001126126,0.0006590676,0.001227138,0.003626331],"category_scores_gemma":[0.0005681823,0.0001880452,0.0004463683,0.001801154,0.0004412841,0.001542749,0.0007782013,0.002096494,0.001812051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006133012,"about_ca_system_score_gemma":0.0009790676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006233238,"about_ca_topic_score_gemma":0.001056792,"domain_scores_codex":[0.9998543,0.00002845717,0.00001942573,0.00002292585,0.00005752071,0.00001724945],"domain_scores_gemma":[0.9997812,0.00009537957,0.00002549632,0.000007012913,0.00006294815,0.00002797026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009840613,0.00005578163,0.0001735643,0.0202612,0.00009766146,0.0005140681,0.00009875172,0.0003985019,0.002987636,0.006644115,0.04929242,0.9193778],"study_design_scores_gemma":[0.00001004662,0.00006639044,0.0004749985,0.002108325,0.00005326157,0.001405173,0.00004594312,0.00004526269,0.0002564705,0.001921237,0.9936019,0.000010974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007293282,0.9984741,0.00008174674,0.0003169175,0.0002965863,0.000001638074,0.000009443434,0.00000736745,0.0007393433],"genre_scores_gemma":[0.0004278563,0.9985585,0.00009897042,0.0002356222,0.0002221254,0.000002381324,0.00001709867,0.000001362678,0.0004361317],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003626331,"threshold_uncertainty_score":0.01213121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391951564256695,"score_gpt":0.3480305188664268,"score_spread":0.3241110032238599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}