{"id":"W3119539575","doi":"10.1371/journal.ppat.1009111","title":"TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"Hydro-Québec; Fonds de Recherche du Québec - Santé; Institute of Infection and Immunity; Canadian Institutes of Health Research; Institute of Cancer Research; Canada Research Chairs","keywords":"Biology; Cell biology; TRIF; Innate immune system; Signal transducing adaptor protein; TLR3; Ubiquitin ligase; Endoplasmic reticulum; Signal transduction; Sendai virus; Receptor; Toll-like receptor; Ubiquitin; Biochemistry; Virology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007039955,0.0002924146,0.0005144684,0.0001877344,0.000177191,0.00002430406,0.0003941681,0.0003389977,0.0003011625],"category_scores_gemma":[0.0003455116,0.0002373277,0.0002375617,0.0003985038,0.000290452,0.0001261199,0.00028341,0.0004949993,0.00008573693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007032599,"about_ca_system_score_gemma":0.0003824831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001010481,"about_ca_topic_score_gemma":0.00007778996,"domain_scores_codex":[0.9950128,0.00322215,0.0007055583,0.0004689166,0.0001181477,0.0004724403],"domain_scores_gemma":[0.9985969,0.00006409153,0.0002867713,0.000815925,0.0002119257,0.00002436776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005781475,0.001069047,0.0006060058,0.00005542712,0.0001291955,0.00006066349,0.002515944,0.000001065239,0.9893284,0.0001590056,0.00001197231,0.0002817454],"study_design_scores_gemma":[0.002263633,0.00047577,0.02779525,0.0003551178,0.00003635519,0.00002573321,0.0007157978,0.0000561642,0.9675692,0.00006785712,0.0003789235,0.0002602325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965166,0.001311415,0.00003147195,0.000466167,0.0002353852,0.001090777,0.0002464303,0.00005356346,0.00004813246],"genre_scores_gemma":[0.9983556,0.00002201865,0.0001123489,0.0001042437,0.00001975073,0.000147632,0.0001583869,0.00003885882,0.00104119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02718924,"threshold_uncertainty_score":0.9677942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181729443174184,"score_gpt":0.2294522537835402,"score_spread":0.2076349593517984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}