{"id":"W3119576017","doi":"10.1101/2021.01.09.426041","title":"Signatures of Mutational Processes in Human DNA Evolution","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cancer Research UK; William and Ella Owens Medical Research Foundation","keywords":"Biology; Genetics; Human genome; Germline; Genome; DNA; Context (archaeology); Mutation; 1000 Genomes Project; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000467939,0.0001240388,0.0002147915,0.001347166,0.0001871762,0.0004659578,0.0001513933,0.0003295034,0.001140943],"category_scores_gemma":[0.001557132,0.0001135238,0.0001785866,0.001066724,0.0003208603,0.000236021,0.0003540914,0.0002820846,0.000226795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237959,"about_ca_system_score_gemma":0.0001174318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005878469,"about_ca_topic_score_gemma":0.0006086453,"domain_scores_codex":[0.9996611,0.0000880357,0.00002277556,0.0001231167,0.00007494422,0.0000299892],"domain_scores_gemma":[0.9990935,0.0003604018,0.000283604,0.00009852731,0.0001016283,0.00006235089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001178142,0.00006180696,0.4275676,0.0003420827,0.0002850282,0.0005686384,0.0005217661,0.005868257,0.5231411,0.003451699,0.0004230363,0.03659073],"study_design_scores_gemma":[0.00002669828,0.0001817559,0.9163496,0.00003379901,0.00009644322,0.002077015,0.0001847715,0.01335629,0.05943931,0.004816103,0.003404508,0.00003371929],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948111,0.0006601525,0.002705008,0.00004624809,0.000005749937,0.000007728485,0.0005134016,0.00006748523,0.001183227],"genre_scores_gemma":[0.9979151,0.0001011555,0.001475679,0.00001819284,0.000005138861,0.000004379806,0.000298862,0.00001071686,0.0001707851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347166,"threshold_uncertainty_score":0.003816843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00789162052417715,"score_gpt":0.2249188479912881,"score_spread":0.217027227467111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}