{"id":"W3119592168","doi":"10.3390/biom11010065","title":"Endolysosomal TRPMLs in Cancer","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Cancer; Cancer cell; Biology; TFEB; Cell biology; Intracellular; Cell growth; Transcription factor; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001431443,0.000387782,0.001008975,0.0001467025,0.00003285064,0.00004384866,0.0002953548,0.0004364766,0.00006501097],"category_scores_gemma":[0.00007392947,0.0003459059,0.000575755,0.0002955056,0.00008975554,0.000001001095,0.0001833387,0.0001859399,0.00002367463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000262829,"about_ca_system_score_gemma":0.0003558236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001168348,"about_ca_topic_score_gemma":0.0001245962,"domain_scores_codex":[0.9982119,0.0002138513,0.0004432889,0.0006444766,0.0001418223,0.0003447036],"domain_scores_gemma":[0.9992486,0.00001821565,0.0001529627,0.0004482574,0.00004366533,0.00008830157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005063502,0.00008230616,0.000005716297,0.001296946,0.0001359411,0.00007908983,0.000005932985,8.765051e-7,0.005732988,0.0001805887,0.001059795,0.9914148],"study_design_scores_gemma":[0.0002190041,0.00002743032,0.00000404645,0.002406853,0.0001855901,0.00004759466,0.000007837449,5.496261e-7,0.003195243,0.000002993095,0.9935105,0.0003923321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002248134,0.9985429,0.00004341703,0.00002385325,0.0004190707,0.0002284535,0.0001202944,0.00001403018,0.0003831444],"genre_scores_gemma":[0.0001352011,0.9976687,0.0001561913,0.00007283618,0.0006244717,0.000140446,0.0005088292,0.00007687103,0.0006164386],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924507,"threshold_uncertainty_score":0.9998993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05681696108945119,"score_gpt":0.3834675287691865,"score_spread":0.3266505676797354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}