{"id":"W3119600319","doi":"10.1073/pnas.2017742118","title":"Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"TREM2; Microglia; Receptor; Alzheimer's disease; Amyloid (mycology); Immunology; Phagocytosis; Neuroscience; Medicine; Biology; Disease; Cell biology; Inflammation; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740622,0.0004508191,0.000324344,0.0004326127,0.0002008388,0.0003666618,0.0001677714,0.0005240948,0.001698669],"category_scores_gemma":[0.0001096155,0.0002812323,0.000314749,0.0001352783,0.0003158928,0.0002960982,0.0002023392,0.001304899,0.0006717399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003405085,"about_ca_system_score_gemma":0.0002079513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994693,"about_ca_topic_score_gemma":0.001567578,"domain_scores_codex":[0.9997409,0.00003308571,0.0000236719,0.00006565995,0.00005162687,0.00008505429],"domain_scores_gemma":[0.9998523,0.00001053607,0.00003476166,0.0000137545,0.00001592328,0.00007266917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005285317,0.00009559232,0.000272705,0.00003749995,0.000005644944,0.0000699201,0.00004189103,0.00005769572,0.9979602,0.00008304509,0.00008535964,0.0007619534],"study_design_scores_gemma":[0.0001323773,0.002031713,0.02327444,0.00003919587,0.00006995734,0.0008275856,0.0002585285,0.002395409,0.9675075,0.0003439791,0.003088971,0.00003026397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954649,0.0007269218,0.001111875,0.000160316,0.00005570721,0.00002829751,0.0008830834,0.00006931671,0.001499703],"genre_scores_gemma":[0.9908626,0.0007684938,0.002662549,0.0001864498,0.00002128093,0.0001031779,0.000661384,0.00003640361,0.004697715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698669,"threshold_uncertainty_score":0.005682647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09747514167358907,"score_gpt":0.3252004396056843,"score_spread":0.2277252979320953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}