{"id":"W3119600980","doi":"10.3390/biom11010075","title":"Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Biology; Neurodevelopmental disorder; Mutation; Neuroscience; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003937676,0.00055917,0.0006954157,0.001194935,0.0002094778,0.0008034399,0.0004353972,0.0008462835,0.0009367611],"category_scores_gemma":[0.0003488699,0.0001813908,0.0004161198,0.0005650082,0.0003773133,0.0008269969,0.0005021651,0.001104533,0.0005063769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005826648,"about_ca_system_score_gemma":0.0005679706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007954991,"about_ca_topic_score_gemma":0.001016788,"domain_scores_codex":[0.9998512,0.00002122513,0.00002256062,0.00003900929,0.00003586125,0.00003006065],"domain_scores_gemma":[0.9998222,0.00005811878,0.00004012963,0.000005279961,0.00004194102,0.00003226331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000543547,0.0001498004,0.006150397,0.009882702,0.0002773031,0.003291919,0.0003128442,0.0008188684,0.06516282,0.009095442,0.01997674,0.8843376],"study_design_scores_gemma":[0.00006193612,0.0006654225,0.01882165,0.003102751,0.0009392042,0.02049882,0.0004790727,0.001419464,0.03071074,0.009722776,0.91344,0.0001380899],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002377158,0.9945502,0.0007839343,0.0007971944,0.0001966711,0.000006276225,0.00004544831,0.00003380902,0.001209371],"genre_scores_gemma":[0.01815914,0.9777594,0.001556069,0.0005610936,0.0007602102,0.00001760553,0.0001868858,0.000008927862,0.0009908151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001194935,"threshold_uncertainty_score":0.004227579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465466429008419,"score_gpt":0.2644758453187348,"score_spread":0.2498211810286506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}