{"id":"W3119600980","doi":"10.3390/biom11010075","title":"Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease","year":2021,"lang":"en","type":"review","venue":"Biomolecules","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Biology; Neurodevelopmental disorder; Mutation; Neuroscience; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001717329,0.0003389009,0.0009212866,0.0001778917,0.00002293312,0.000008811917,0.0002393574,0.0003171373,0.00001125621],"category_scores_gemma":[0.00008571576,0.0003169456,0.0002422714,0.0002108551,0.0001461163,0.000001690502,0.0003693209,0.0001003475,0.000001374675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001190047,"about_ca_system_score_gemma":0.0002531296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000133409,"about_ca_topic_score_gemma":0.00001536557,"domain_scores_codex":[0.9982195,0.0002470961,0.0005717273,0.0005924049,0.0001197257,0.0002495752],"domain_scores_gemma":[0.9991714,0.00001379252,0.0003136311,0.0003592388,0.00004426307,0.00009762464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000186157,0.0001262298,0.00001554138,0.004278048,0.000145193,0.00004621374,0.00001583377,1.463838e-7,0.9326006,0.00126632,0.000009539044,0.06147775],"study_design_scores_gemma":[0.001470435,0.001490428,0.0004040847,0.01642787,0.0009235077,0.0002323277,0.0003486979,0.000008023565,0.7020434,0.001799997,0.2724394,0.002411828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1388832,0.8602257,0.0000285751,0.000008802876,0.00004137713,0.0005450626,0.0002122046,0.000003348625,0.0000516422],"genre_scores_gemma":[0.06707445,0.9315372,0.0005777149,0.000009596531,0.000005764877,0.0001426322,0.0005261704,0.00005067057,0.00007587907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2724299,"threshold_uncertainty_score":0.9999282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465466429008419,"score_gpt":0.2644758453187348,"score_spread":0.2498211810286506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}